Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HK1 | P19367 | 1/20 | 0.41 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 12/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2541818 | 0.96 | SMN1; SMN2 (0.44) | SMN1; SMN2ALDH1A1HK1HKDC1PTGDR2 | |
| SCHEMBL1422452 | 0.86 | PTGDR2 (0.52) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL2544964 | 0.81 | PTGDR2 (0.50) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL1599839 | 0.79 | PTGDR2 (0.47) | SMN1; SMN2ALDH1A1HK1HKDC1PTGDR2 | |
| SCHEMBL1465979 | 0.77 | PTGDR2 (0.46) | ALDH1A1HK1HKDC1PTGDR2PTGDR | |
| SCHEMBL2539312 | 0.76 | PTGDR2 (0.47) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL1466409 | 0.74 | PTGDR2 (0.56) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL1465369 | 0.73 | ALDH1A1 (0.47) | SMN1; SMN2ALDH1A1HK1HKDC1PTGDR2 | |
| SCHEMBL1465051 | 0.73 | PTGDR2 (0.51) | ALDH1A1HK1HKDC1PTGDR2PTGDR | |
| SCHEMBL1783342 | 0.73 | PTGDR2 (0.51) | PTGDR2PTGDRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856045-A1 | 1-ACETIC ACID-INDOLE DERIVATIVES WITH PGD2 ANTAGONIST ACTIVITY | Oxagen Limited (GB) | 2007-11-21 | — | — | EP | disclosed |
| WO-2006095183-A1 | 1-ACETIC ACID-INDOLE DERIVATIVES WITH PGD2 ANTAGONIST ACTIVITY | OXAGEN LIMITED (GB) | 2006-09-14 | — | — | WO | disclosed |