Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 20/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.47 |
| ▸ | PTGDR | Q13258 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2539312 | 0.89 | PTGDR2 (0.47) | PTGDR2AKR1B1PTGDRCYP2C9 | |
| SCHEMBL1422452 | 0.85 | PTGDR2 (0.52) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL2544964 | 0.83 | PTGDR2 (0.50) | PTGDR2AKR1B1PTGDRCYP2C9 | |
| SCHEMBL2910370 | 0.78 | LGALS8 (0.34) | PTGDR2 | |
| SCHEMBL2541818 | 0.76 | SMN1; SMN2 (0.44) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL1467977 | 0.76 | PTGDR2 (0.62) | PTGDR2AKR1B1PTGDRCYP2C9 | |
| SCHEMBL5320658 | 0.73 | SMN1; SMN2 (0.41) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL1466556 | 0.72 | PTGDR2 (0.75) | PTGDR2PTGDR | |
| SCHEMBL1466409 | 0.72 | PTGDR2 (0.56) | PTGDR2PTGDRCYP2C9 | |
| SCHEMBL1787716 | 0.72 | PTGDR2 (0.64) | PTGDR2AKR1B1PTGDRCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3083557-B1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | ATOPIX THERAPEUTICS LTD (GB) | 2017-11-29 | — | — | EP | claimed |
| US-9828359-B2 | Process for the preparation of 3-substituted (indol-1-yl)-acetic acid esters | ATOPIX THERAPEUTICS LIMITED (GB) | 2017-11-28 | — | — | US | claimed |
| US-20170305879-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | ZACH SYSTEM SPA (IT) | 2017-10-26 | — | — | US | claimed |
| EP-3083557-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | Atopix Therapeutics Limited (GB) | 2016-10-26 | — | — | EP | claimed |
| WO-2015092372-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | ATOPIX THERAPEUTICS LIMITED (GB) | 2015-06-25 | — | — | WO | claimed |
| US-20140328861-A1 | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis | ATOPIX THERAPEUTICS LTD (GB) | 2014-11-06 | — | — | US | claimed |
| EP-2790696-A1 | COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS | Atopix Therapeutics Limited (GB) | 2014-10-22 | — | — | EP | claimed |
| WO-2013088109-A1 | COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS | OXAGEN LIMITED (GB) | 2013-06-20 | — | — | WO | claimed |
| US-20130052190-A1 | CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions | OXAGEN LIMITED (GB) | 2013-02-28 | — | — | US | claimed |
| US-20110124683-A1 | Use of CRTH2 Antagonist Compounds | OXAGEN LIMITED (GB) | 2011-05-26 | — | — | US | claimed |
| EP-3083557-B1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | ATOPIX THERAPEUTICS LTD (GB) | 2017-11-29 | — | — | EP | disclosed |
| US-9828359-B2 | Process for the preparation of 3-substituted (indol-1-yl)-acetic acid esters | ATOPIX THERAPEUTICS LIMITED (GB) | 2017-11-28 | — | — | US | disclosed |
| US-20170305879-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | ZACH SYSTEM SPA (IT) | 2017-10-26 | — | — | US | disclosed |
| EP-3083557-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | Atopix Therapeutics Limited (GB) | 2016-10-26 | — | — | EP | disclosed |
| WO-2015092372-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | ATOPIX THERAPEUTICS LIMITED (GB) | 2015-06-25 | — | — | WO | disclosed |
| US-20140328861-A1 | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis | ATOPIX THERAPEUTICS LTD (GB) | 2014-11-06 | — | — | US | disclosed |
| EP-2790696-A1 | COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS | Atopix Therapeutics Limited (GB) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013088109-A1 | COMBINATION OF CRTH2 ANTAGONIST AND A PROTON PUMP INHIBITOR FOR THE TREATMENT OF EOSINOPHILIC ESOPHAGITIS | OXAGEN LIMITED (GB) | 2013-06-20 | — | — | WO | disclosed |
| US-20130052190-A1 | CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions | OXAGEN LIMITED (GB) | 2013-02-28 | — | — | US | disclosed |
| US-20110124683-A1 | Use of CRTH2 Antagonist Compounds | OXAGEN LIMITED (GB) | 2011-05-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110124683-A1 | Use of CRTH2 Antagonist Compounds | HRH2, HRH1, HRH4 | PTGDR2 25/4885AKR1B1 271/4885PTGDR 47/4885 |
| US-20130052190-A1 | CRTH2 Antagonists for Treatment of Eosinophilic Diseases and Conditions | HRH2, HRH1, HRH4 | PTGDR2 58/4885AKR1B1 668/4885PTGDR 119/4885 |
| US-20140328861-A1 | Combination of CRTH2 Antagonist and a Proton Pump Inhibitor for the Treatment of Eosinophilic Esophagitis | HRH2, HRH1, HRH4 | PTGDR2 59/4885AKR1B1 3801/4885PTGDR 108/4885 |
| US-20170305879-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | IDO1, IDO2, SI | PTGDR2 1790/4885AKR1B1 118/4885PTGDR 1547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.