Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.43 |
| ▸ | GCGR | P47871 | 4/20 | 0.43 |
| ▸ | AKT1 | P31749 | 2/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | MATK | P42679 | 1/20 | 0.35 |
| ▸ | FRK | P42685 | 1/20 | 0.35 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5342012 | 0.83 | AKT1 (0.44) | AKT1AKT2PTGS1PTGS2MAPT | |
| SCHEMBL5344560 | 0.81 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11GCGR | |
| SCHEMBL5320129 | 0.79 | AKT1 (0.46) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL5347682 | 0.78 | GRM5 (0.39) | AKT1AKT2GRM5 | |
| SCHEMBL5319387 | 0.78 | AKT1 (0.41) | MAPK14AKT1AKT2PTGS1PTGS2 | |
| SCHEMBL5354165 | 0.78 | AKT1 (0.44) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL5341386 | 0.75 | AKT1 (0.49) | AKT1AKT2PTGS2GRM5GSK3B | |
| SCHEMBL5324372 | 0.75 | AKT1 (0.55) | AKT1AKT2PTGS2GRM5MAPT | |
| SCHEMBL5321674 | 0.75 | AKT1 (0.45) | MAPK14MAPK13MAPK12MAPK11AKT1 | |
| SCHEMBL6102319 | 0.74 | MAPT (0.53) | MAPK14MAPK13MAPK12MAPK11GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096764-A2 | BICYCLIC HETEROARYL DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | GLENMARK PHARMACEUTICALS S.A. (US) | 2007-08-30 | — | — | WO | claimed |
| WO-2007096764-A2 | BICYCLIC HETEROARYL DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS | GLENMARK PHARMACEUTICALS S.A. (US) | 2007-08-30 | — | — | WO | disclosed |