Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3175510 | 0.84 | CA1 (0.36) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL16245702 | 0.83 | CA1 (0.34) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL24049964 | 0.81 | KDM4E (0.49) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL5347897 | 0.81 | CA1 (0.36) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL4411003 | 0.79 | CA1 (0.36) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL31319651 | 0.79 | GABRA5 (0.36) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL29953477 | 0.79 | CA1 (0.33) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL16245642 | 0.75 | CA1 (0.35) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL24049966 | 0.74 | AAK1 (0.36) | CA1CA2CA12CA9PSMB8 | |
| SCHEMBL27042890 | 0.73 | CYP17A1 (0.34) | CA1CA2CA12CA9PSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109456-A2 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | PHARMACOPEIA, INC. (US) | 2007-09-27 | — | — | WO | disclosed |