Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532611 | 0.82 | NPSR1 (0.37) | MEN1KMT2AGHSRATMALDH1A1 | |
| SCHEMBL532201 | 0.80 | CYP1A2 (0.38) | MEN1KMT2AAPLNRATM | |
| SCHEMBL531391 | 0.79 | MEN1 (0.43) | MEN1KMT2ANPC1ATMALDH1A1 | |
| SCHEMBL531534 | 0.77 | MEN1 (0.37) | MEN1KMT2AAPLNRATMALDH1A1 | |
| SCHEMBL739241 | 0.77 | MEN1 (0.40) | MEN1KMT2ANPC1ATMALDH1A1 | |
| SCHEMBL3336723 | 0.73 | MEN1 (0.39) | MEN1KMT2AATMALDH1A1POLB | |
| SCHEMBL531745 | 0.73 | MEN1 (0.41) | MEN1KMT2AATMALDH1A1POLB | |
| SCHEMBL2391342 | 0.73 | KMT2A (0.41) | MEN1KMT2AATMALDH1A1POLB | |
| SCHEMBL531473 | 0.73 | MEN1 (0.41) | MEN1KMT2AATMALDH1A1POLB | |
| SCHEMBL3299395 | 0.72 | TSHR (0.34) | NPC1APLNRALDH1A1CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |