SCHEMBL5322140

SCHEMBL5322140

CCOC(=O)C(Cl)c1ccccc1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CASP1 P29466 1/20 0.57
PIN1 Q13526 1/20 0.44
ALDH1A1 P00352 3/20 0.43
TSHR P16473 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
RAB9A P51151 1/20 0.43
NPC1 O15118 1/20 0.42
NLRP3 Q96P20 1/20 0.41
HPGD P15428 1/20 0.41
MMP8 P22894 1/20 0.41
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
EPHX2 P34913 1/20 0.40
LMNA P02545 1/20 0.40
PDE4B Q07343 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5324567 0.85 TSHR (0.50) CASP1ALDH1A1TSHRMEN1KMT2A
SCHEMBL11003080 0.84 TDP1 (0.45) CASP1PIN1TSHRMEN1KMT2A
SCHEMBL5861445 0.84 CASP1 (0.59) CASP1PIN1ALDH1A1TSHRMEN1
SCHEMBL10708969 0.83 CASP1 (0.57) CASP1PIN1ALDH1A1TSHRMEN1
SCHEMBL4632797 0.83 CASP1 (0.70) CASP1PIN1ALDH1A1TSHRMEN1
SCHEMBL4632799 0.83 CASP1 (0.70) CASP1PIN1ALDH1A1TSHRMEN1
SCHEMBL3697021 0.82 CASP1 (0.45) CASP1ALDH1A1KMT2ACYP2C19
SCHEMBL5252341 0.81 PIN1 (0.42) CASP1PIN1ALDH1A1TSHRMEN1
SCHEMBL5327049 0.81 CASP1 (0.56) CASP1PIN1ALDH1A1TSHRMEN1
SCHEMBL11833412 0.81 CYP1A2 (0.45) CASP1PIN1MEN1KMT2ARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103387490-B A kind of method of toluene carboxylation to synthesize phenylacetic acid LANZHOU INSTITUTE OF CHEMICAL PHYSICS, CHINESE ACADEMY OF SCIENCES (CN) 2015-08-26 CN disclosed
WO-2007126258-A1 THE METHOD OF MAKING OPTICALLY ACTIVE 2-HALO-2-(N-SUBSTITUTED PHENYL)ACETIC ACID ESTERS AND 2-HALO-2-(N-SUBSTITUTED PHENYL)ACETIC ACIDS BY ENZYMATIC METHOD ENZYTECH, LTD (KR) 2007-11-08 WO disclosed
US-5556854-A CARDIOVASCULAR DISORDERS AND/OR NEUROGENERATIVE DISORDERS HOECHST AKTIENGESELLSCHAFT (DE) 1996-09-17 US disclosed