Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 17/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322205 | 1.00 | RET (0.47) | RETKDRALDH1A1CSF1RKIT | |
| SCHEMBL2450824 | 0.88 | RET (0.62) | RETKDRCSF1RKITPDGFRA | |
| SCHEMBL2450820 | 0.88 | RET (0.62) | RETKDRCSF1RKITPDGFRA | |
| SCHEMBL12303679 | 0.88 | RET (0.62) | RETKDRCSF1RKITPDGFRA | |
| SCHEMBL2450822 | 0.88 | RET (0.62) | RETKDRCSF1RKITPDGFRA | |
| SCHEMBL2453347 | 0.85 | ALDH1A1 (0.46) | RETKDRALDH1A1CSF1RKIT | |
| SCHEMBL2450805 | 0.79 | RET (0.64) | RETKDRCSF1RKITPDGFRA | |
| SCHEMBL2450807 | 0.79 | RET (0.64) | RETKDRCSF1RKITPDGFRA | |
| SCHEMBL2450638 | 0.74 | RET (0.54) | RETKDRALDH1A1PDGFRA | |
| SCHEMBL2448477 | 0.71 | RET (0.65) | RETKDRCSF1RKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109783-A2 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-09-27 | — | — | WO | disclosed |