Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322226 | 1.00 | TAAR1 (0.47) | TAAR1LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL5322220 | 1.00 | TAAR1 (0.47) | TAAR1LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL2302219 | 0.84 | SLC6A4 (0.52) | TAAR1LMNAMAPK1HTTSMN1; SMN2 | |
| SCHEMBL17220460 | 0.80 | TDP1 (0.48) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL17220459 | 0.80 | TDP1 (0.48) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL31071592 | 0.76 | SLC6A2 (0.63) | TAAR1HTR6SLC6A4CYP2D6SLC6A2 | |
| SCHEMBL5327707 | 0.75 | SLC6A4 (0.46) | HTR6SLC6A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5329150 | 0.75 | SLC6A4 (0.46) | HTR6SLC6A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5327705 | 0.75 | SLC6A4 (0.46) | HTR6SLC6A4CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL5332291 | 0.75 | GRM2 (0.48) | GRM2KDM4EALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |