Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTH1R | Q03431 | 17/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5326444 | 0.90 | PTH1R (0.54) | PTH1RNPC1TP53TSHRRAB9A | |
| SCHEMBL5328105 | 0.85 | PTH1R (0.54) | PTH1RMEN1MAPTKMT2A | |
| SCHEMBL5320662 | 0.85 | PTH1R (0.54) | PTH1RMEN1MAPTKMT2A | |
| SCHEMBL5320370 | 0.85 | PTH1R (0.48) | PTH1RGAASMN1; SMN2MAPT | |
| SCHEMBL5326447 | 0.82 | PTH1R (0.52) | PTH1R | |
| SCHEMBL5329302 | 0.76 | PTH1R (0.49) | PTH1RKMT2A | |
| SCHEMBL14566434 | 0.75 | PTH1R (0.57) | PTH1RTP53 | |
| SCHEMBL5322910 | 0.74 | PTH1R (0.79) | PTH1R | |
| SCHEMBL5321537 | 0.74 | PTH1R (0.73) | PTH1R | |
| SCHEMBL5325632 | 0.74 | PTH1R (0.54) | PTH1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006129120-A9 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-03-22 | — | — | WO | disclosed |
| WO-2006129120-A2 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2006-12-07 | — | — | WO | disclosed |