SCHEMBL532282 — predicted protein targets

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	HTT	P42858	3/20	0.55

▸	HPGD	P15428	2/20	0.55

▸	ALDH1A1	P00352	5/20	0.52

▸	HSP90AA1	P07900	1/20	0.52

▸	CACNA1B	Q00975	1/20	0.52

▸	APBA1	Q02410	1/20	0.52

▸	NPSR1	Q6W5P4	1/20	0.52

▸	TDP1	Q9NUW8	1/20	0.52

▸	MEN1	O00255	2/20	0.52

▸	KMT2A	Q03164	2/20	0.52

▸	TSHR	P16473	1/20	0.50

▸	CA12	O43570	1/20	0.50

▸	CA1	P00915	1/20	0.50

▸	CA2	P00918	1/20	0.50

▸	ESR1	P03372	1/20	0.50

▸	CA7	P43166	1/20	0.50

▸	CA9	Q16790	1/20	0.50

▸	ESR2	Q92731	1/20	0.50

▸	CA14	Q9ULX7	1/20	0.50

▸	LMNA	P02545	2/20	0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL22015905	0.88	HPGD (0.65)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL20188098	0.88	HPGD (0.65)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL532250	0.87	ALDH1A1 (0.57)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL6132742	0.85	ALDH1A1 (0.53)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL3898465	0.84	HPGD (0.61)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL28242074	0.84	HPGD (0.61)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL10770347	0.84	HPGD (0.56)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL20187714	0.83	HPGD (0.59)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL3900474	0.83	SIRT2 (0.60)	HTTHPGDALDH1A1HSP90AA1CACNA1B
SCHEMBL4690718	0.82	MEN1 (0.71)	HTTHPGDALDH1A1HSP90AA1CACNA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-8669249-B2	Poly (ADP-ribose) polymerase (PARP) inhibitors	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2014-03-11	—	—	US	disclosed
US-8669249-B2	Poly (ADP-ribose) polymerase (PARP) inhibitors	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2014-03-11	—	—	US	disclosed
US-8669249-B2	Poly (ADP-ribose) polymerase (PARP) inhibitors	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2014-03-11	—	—	US	disclosed
US-20120094992-A1	POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2012-04-19	—	—	US	disclosed
US-20120094992-A1	POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2012-04-19	—	—	US	disclosed
US-20120094992-A1	POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2012-04-19	—	—	US	disclosed
EP-2415767-A1	Poly (ADP-ribose) Polymerase (PARP) Inhibitors	Takeda Pharmaceutical Company Limited (JP)	2012-02-08	—	—	EP	disclosed
EP-2415767-A1	Poly (ADP-ribose) Polymerase (PARP) Inhibitors	Takeda Pharmaceutical Company Limited (JP)	2012-02-08	—	—	EP	disclosed
WO-2010111626-A2	POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2010-09-30	—	—	WO	disclosed
WO-2010111626-A2	POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2010-09-30	—	—	WO	disclosed
US-7754886-B2	N-acylsulfonamide apoptosis promoters	ABBOTT LABORATORIES (US)	2010-07-13	—	—	US	disclosed
US-20090137585-A1	N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS	ABBOTT LABORATORIES (US)	2009-05-28	—	—	US	disclosed
US-7504512-B2	N-acylsulfonamide apoptosis promoters	ABBOTT LABORATORIES (US)	2009-03-17	—	—	US	disclosed
EP-1318978-B1	N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS	ABBOTT LAB (US)	2006-02-08	—	—	EP	disclosed
US-20040192681-A1	N-acylsulfonamide apoptosis promoters	ABBVIE INC.	2004-09-30	—	—	US	disclosed
US-6720338-B2	BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL	ABBOTT LABORATORIES	2004-04-13	—	—	US	disclosed
EP-1318978-A2	N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS	Abbott Laboratories (US)	2003-06-18	—	—	EP	disclosed
US-20020086887-A1	N-Acylsulfonamide apoptosis promoters	ABBVIE INC.	2002-07-04	—	—	US	disclosed
US-20020055631-A1	N-acylsulfonamide apoptosis promoters	ABBOTT LABORATORIES	2002-05-09	—	—	US	disclosed
WO-2002024636-A2	N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS	ABBOTT LABORATORIES (US)	2002-03-28	—	—	WO	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20020086887-A1	N-Acylsulfonamide apoptosis promoters	BAX, BCLAF1, BCL2	HTT 3524/4885HPGD 2505/4885ALDH1A1 2651/4885
US-20020055631-A1	N-acylsulfonamide apoptosis promoters	BAX, BCLAF1, BCL2	HTT 3398/4885HPGD 2709/4885ALDH1A1 2460/4885
US-20040192681-A1	N-acylsulfonamide apoptosis promoters	BAX, BCLAF1, BCL2	HTT 3524/4885HPGD 2505/4885ALDH1A1 2651/4885
US-20090137585-A1	N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS	BAX, BCL2, BCOR	HTT 2725/4885HPGD 2354/4885ALDH1A1 3404/4885
US-20120094992-A1	POLY (ADP-RIBOSE) POLYMERASE (PARP) INHIBITORS	PARP1, PARP2, PARP3	HTT 2124/4885HPGD 247/4885ALDH1A1 445/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.