Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | F7 | P08709 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL415278 | 0.85 | FGFR1 (0.64) | LMNAMRGPRX1CSF1RKMT2AMEN1 | |
| SCHEMBL30682065 | 0.79 | CSF1R (0.52) | LMNAMRGPRX1CSF1RKMT2AMEN1 | |
| SCHEMBL2999856 | 0.78 | AURKB (0.51) | CSF1RL3MBTL1FGFR1 | |
| SCHEMBL417146 | 0.77 | FGFR1 (0.65) | LMNACSF1RKMT2AFGFR1FGFR4 | |
| SCHEMBL5138865 | 0.77 | LMNA (0.44) | LMNAMRGPRX1KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5328761 | 0.77 | AURKB (0.39) | CSF1RFGFR1 | |
| SCHEMBL856028 | 0.77 | FGFR1 (0.58) | LMNACSF1RKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL30682073 | 0.76 | CSF1R (0.56) | LMNACSF1RNPC1RAB9A | |
| SCHEMBL5345274 | 0.76 | KDR (0.42) | LMNACSF1RKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL1362778 | 0.75 | FGFR1 (0.54) | CSF1RFGFR1FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |