Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.35 |
| ▸ | CCNK | O75909 | 1/20 | 0.34 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL411641 | 0.85 | FGFR1 (0.51) | KDRFLT1BRD4CSF1RPLK1 | |
| SCHEMBL5328761 | 0.81 | AURKB (0.39) | KDRFLT1CSF1RNUDT1CCNK | |
| SCHEMBL416754 | 0.78 | MET (0.55) | BRD4CSF1RCTSVCTSLLMNA | |
| SCHEMBL14620821 | 0.76 | FGFR1 (0.50) | BRD4CSF1RKMT2ANPSR1CCNT1 | |
| SCHEMBL415103 | 0.76 | FGFR1 (0.53) | KDRFLT1BRD4CSF1REPHA2 | |
| SCHEMBL5322848 | 0.76 | LMNA (0.52) | CSF1RABCB1MEN1LMNAKMT2A | |
| SCHEMBL414646 | 0.75 | FGFR1 (0.49) | KDRFLT1BRD4CSF1RPLK1 | |
| SCHEMBL415163 | 0.75 | GPR84 (0.47) | KDRBRD4CSF1R | |
| SCHEMBL413608 | 0.72 | FGFR1 (0.43) | BRD4CSF1RKMT2ANPSR1CCNT1 | |
| SCHEMBL415740 | 0.71 | GPR84 (0.51) | BRD4CSF1RERBB2ABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |