Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19348988 | 1.00 | CYP2D6 (0.39) | CYP2D6ATMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL17846081 | 1.00 | CYP2D6 (0.39) | CYP2D6ATMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL18222261 | 0.85 | BRD4 (0.38) | CYP2D6KMT2AMEN1LMNACYP2C19 | |
| SCHEMBL1936243 | 0.77 | CYP2D6 (0.43) | CYP2D6KDM4EKMT2AMEN1SRC | |
| SCHEMBL4352633 | 0.76 | KDM4E (0.39) | CYP2D6ATMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL1274248 | 0.76 | KDM4E (0.39) | CYP2D6ATMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL28340791 | 0.75 | ATM (0.41) | CYP2D6ATMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL3326907 | 0.75 | AOC3 (0.44) | CYP2D6ATMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL17076397 | 0.74 | ATM (0.40) | CYP2D6ATMKDM4EKMT2AL3MBTL1 | |
| SCHEMBL17076396 | 0.74 | ATM (0.40) | CYP2D6ATMKDM4EKMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160075724-A1 | CETP Inhibitors | MERCK SHARP & DOHME (US) | 2016-03-17 | — | — | US | disclosed |
| US-20140221383-A1 | CETP INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | US | disclosed |
| US-8735435-B2 | CETP inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-05-27 | — | — | US | disclosed |
| EP-1765793-B1 | ANACETRAPIB AND OTHER CETP INHIBITPRS | MERCK SHARP & DOHME (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2415759-A1 | CETP inhibitors | Merck Sharp & Dohme Corporation (US) | 2012-02-08 | — | — | EP | disclosed |
| US-20100099716-A1 | CETP INHIBITORS | MERCK SHARP & DOHME LLC | 2010-04-22 | — | — | US | disclosed |
| US-7652049-B2 | 1-benzyl-4-[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]imidazolidin-2-one; cholesteryl ester transfer protein inhibitor; raising HDL-cholesterol, reducing LDL-cholesterol; atherosclerosis; antiinflammatory agent; synergistic mixture with other active ingredients | MERCK & CO., INC. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20080119476-A1 | Cetp Inhibitors | ALI AMJAD | 2008-05-22 | — | — | US | disclosed |
| US-20060040999-A1 | CETP inhibitors | MERCK SHARP & DOHME LLC | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221383-A1 | CETP INHIBITORS | CETP, APOB, MTTP | CYP2D6 731/4885ATM 1904/4885KDM4E 1437/4885 |
| US-20060040999-A1 | CETP inhibitors | CETP, APOB, MTTP | CYP2D6 731/4885ATM 1904/4885KDM4E 1437/4885 |
| US-20080119476-A1 | Cetp Inhibitors | CETP, APOB, MTTP | CYP2D6 731/4885ATM 1904/4885KDM4E 1437/4885 |
| US-20100099716-A1 | CETP INHIBITORS | CETP, APOB, MTTP | CYP2D6 731/4885ATM 1904/4885KDM4E 1437/4885 |
| US-20160075724-A1 | CETP Inhibitors | CETP, APOB, MTTP | CYP2D6 731/4885ATM 1904/4885KDM4E 1437/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.