⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4662274 | 0.83 | — | — | |
| SCHEMBL11288475 | 0.80 | — | — | |
| SCHEMBL7487262 | 0.78 | — | — | |
| SCHEMBL10385577 | 0.76 | — | — | |
| SCHEMBL4087560 | 0.76 | ALDH1A1 (0.37) | — | |
| Hydrochloric Acid SCHEMBL11687841 | 0.76 | ALDH1A1 (0.37) | — | |
| SCHEMBL7995698 | 0.76 | — | — | |
| SCHEMBL27950 | 0.74 | ALDH1A1 (0.40) | — | |
| SCHEMBL4258920 | 0.74 | ALDH1A1 (0.40) | — | |
| SCHEMBL3652188 | 0.72 | ALDH1A1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1852422-A2 | Nitrosated and nitorsylated alpha-andrenergic receptor antagonist compounds, compositions and their uses | Nitromed, Inc. (US) | 2007-11-07 | — | — | EP | claimed |
| US-20020173659-A1 | Indole derivatives for the treatment of osteoporosis | SMITH KLINE BEECHAM SPA | 2002-11-21 | — | — | US | claimed |
| US-6037345-A | Method for inhibiting neoplastic cells and related conditions by exposure to quinazolinedione and pyridopyrimidinedione derivatives | CELL PATHWAYS, INC. (US) | 2000-03-14 | — | — | US | claimed |
| US-4880810-A | Quinazolinediones and pyridopyrimidinediones | PFIZER INC. (US) | 1989-11-14 | — | — | US | claimed |
| CN-108064173-B | Partial insulin receptor agonists | 默沙东公司 | 2021-05-18 | — | — | CN | disclosed |
| US-20140200209-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | VIIV HEALTHCARE COMPANY (US) | 2014-07-17 | — | — | US | disclosed |
| US-20130172559-A1 | POLYCYCLIC CARBAMOYLPYRIDONE DERIVATIVE HAVING HIV INTEGRASE INHIBITORY ACTIVITY | VIIV HEALTHCARE COMPANY (US) | 2013-07-04 | — | — | US | disclosed |
| US-20060247217-A1 | Tricyclic protein kinase inhibitors | BERGER DAN M | 2006-11-02 | — | — | US | disclosed |
| US-20050070558-A1 | 6-Phenyldihydropyrrolopyrimidinedione derivatives | ALMIRALL PRODESFARMA S.A. (ES) | 2005-03-31 | — | — | US | disclosed |
| US-4818247-A | COLORFASTNESS | CIBA-GEIGY CORPORATION (US) | 1989-04-04 | — | — | US | disclosed |
| US-3931268-A | Methylhydrazinomethyl-substituted benzoic acid amides | HOFFMANN-LA ROCHE INC. (US) | 1976-01-06 | — | — | US | disclosed |