Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 9/20 | 0.55 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 4/20 | 0.35 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.34 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812428 | 0.92 | MAPK14 (0.55) | MAPK14VNN1SLC16A3MAP2K4MAPK1 | |
| SCHEMBL7474456 | 0.87 | MAPK14 (0.52) | MAPK14MAP2K4MAPK1MAPK6 | |
| SCHEMBL1383396 | 0.87 | MAPK14 (0.52) | MAPK14MAP2K4MAPK1MAPK6HSD17B14 | |
| Hydrochloric Acid SCHEMBL7473782 | 0.86 | MAPK14 (0.51) | MAPK14MAP2K4MAPK1MAPK6HSD17B14 | |
| SCHEMBL7476872 | 0.85 | MAPK14 (0.45) | MAPK14MAP2K4MAPK1MAPK6 | |
| SCHEMBL7469019 | 0.84 | MAPK14 (0.43) | MAPK14VNN1MAP2K4 | |
| SCHEMBL1385251 | 0.83 | MAPK14 (0.55) | MAPK14MAP2K4 | |
| SCHEMBL7470777 | 0.82 | MAPK1 (0.40) | MAPK14MAPK1 | |
| SCHEMBL7477623 | 0.82 | MAP2K4 (0.49) | MAP2K4MAP2K7 | |
| SCHEMBL1383366 | 0.81 | MAPK14 (0.57) | MAPK14MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096151-A2 | INHIBITORS OF P38-KINASE FOR TREATMENT OF PULMONARY HYPERTENSION | NOVARTIS AG (CH) | 2007-08-30 | — | — | WO | claimed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | claimed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | claimed |
| EP-1641764-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | Novartis AG (CH) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005009973-A1 | 5-MEMBERED HETEROCYCLE-BASED P38 KINASE INHIBITORS | NOVARTIS AG (CH) | 2005-02-03 | — | — | WO | disclosed |
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |