Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.36 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | SGK1 | O00141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7812428 | 0.88 | MAPK14 (0.55) | MAPK14VNN1MAP2K4 | |
| SCHEMBL5323714 | 0.84 | MAPK14 (0.55) | MAPK14VNN1MAP2K4 | |
| SCHEMBL7474456 | 0.84 | MAPK14 (0.52) | MAPK14MAP2K4MRGPRX4 | |
| SCHEMBL1383396 | 0.84 | MAPK14 (0.52) | MAPK14MAP2K4 | |
| SCHEMBL7469241 | 0.83 | MAPK14 (0.40) | MAPK14MAP2K4MRGPRX4 | |
| Hydrochloric Acid SCHEMBL7473782 | 0.83 | MAPK14 (0.51) | MAPK14MAP2K4 | |
| SCHEMBL7476872 | 0.82 | MAPK14 (0.45) | MAPK14MAP2K4 | |
| SCHEMBL1385251 | 0.82 | MAPK14 (0.55) | MAPK14MAP2K4 | |
| SCHEMBL7470777 | 0.81 | MAPK1 (0.40) | MAPK14 | |
| SCHEMBL7803286 | 0.78 | MAPK14 (0.54) | MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1218346-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-07-03 | — | — | EP | disclosed |
| WO-2001021591-A1 | PYRAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2001-03-29 | — | — | WO | disclosed |
| EP-1075467-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-02-14 | — | — | EP | disclosed |
| WO-1999057101-A1 | PYRAZOLE DERIVATIVES AS P-38 MAP KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 1999-11-11 | — | — | WO | disclosed |