Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11126054 | 0.88 | PDE10A (0.49) | PDE10AGLACYP3A4KMT2AKDM4E | |
| SCHEMBL8313758 | 0.77 | PDE10A (0.47) | PDE10AGLACYP3A4KMT2AKDM4E | |
| SCHEMBL2761711 | 0.74 | MEN1 (0.32) | KMT2AKDM4EMEN1ALDH1A1MAPK1 | |
| SCHEMBL27287019 | 0.74 | CYP3A4 (0.54) | PDE10AGLACYP3A4KMT2AKDM4E | |
| SCHEMBL21091020 | 0.73 | PDE10A (0.55) | PDE10AGLACYP3A4KMT2AKDM4E | |
| SCHEMBL322239 | 0.72 | MEN1 (0.35) | KMT2AKDM4EMEN1ALDH1A1MAPK1 | |
| SCHEMBL8855149 | 0.72 | MEN1 (0.35) | KMT2AKDM4EMEN1ALDH1A1MAPK1 | |
| SCHEMBL5536800 | 0.72 | PDE10A (0.53) | PDE10AGLACYP3A4KMT2AKDM4E | |
| SCHEMBL829862 | 0.72 | PDE10A (0.53) | PDE10AGLACYP3A4KMT2AKDM4E | |
| SCHEMBL13712985 | 0.71 | PDE10A (0.49) | PDE10AGLACYP3A4KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135529-A2 | AZABENZIMIDAZOLYL COMPOUNDS AS MGLUR2 POTENTIATORS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | claimed |
| WO-2007135527-A2 | BENZIMIDAZOLYL COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-29 | — | — | WO | disclosed |