Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5324014 | 0.77 | PDE10A (0.45) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL2096015 | 0.77 | ALDH1A1 (0.59) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL11126054 | 0.74 | PDE10A (0.49) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL8108203 | 0.72 | CCR1 (0.50) | CYP2A6TGFBR1 | |
| SCHEMBL5065334 | 0.72 | PDPK1 (0.43) | CYP2A6ADORA2AADRA1ACYP19A1RAB9A | |
| SCHEMBL5584101 | 0.72 | IDO1 (0.32) | CYP2A6 | |
| SCHEMBL21091020 | 0.72 | PDE10A (0.55) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL24181735 | 0.71 | PDE10A (0.42) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL8198560 | 0.71 | CYP3A4 (0.60) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 | |
| SCHEMBL5536800 | 0.71 | PDE10A (0.53) | PDE10ACYP3A4CYP2E1CYP2A6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901487-A1 | NOVEL 2,3 DISUBSTITUTED-4(3H)-QUINAZOLINONES | PFIZER INC. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043276-A1 | NOVEL 2,3 DISUBSTITUTED-4(3H)-QUINAZOLINONES | PFIZER INC. (US) | 1997-11-20 | — | — | WO | disclosed |