SCHEMBL5324075

SCHEMBL5324075

[c]1oc2ccccc2c1-c1nc2ccccc2o1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 7/20 0.50
RAB9A P51151 5/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
ATM Q13315 1/20 0.50
ALDH1A1 P00352 7/20 0.48
HPGD P15428 6/20 0.48
KDM4E B2RXH2 5/20 0.48
MAPT P10636 4/20 0.48
USP2 O75604 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
HSD17B10 Q99714 6/20 0.47
TP53 P04637 4/20 0.47
SMN1; SMN2 Q16637 4/20 0.47
HCRTR1 O43613 2/20 0.47
PKM P14618 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
ALOX5 P09917 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL824375 0.78 NPC1 (0.69) NPC1RAB9AMEN1KMT2AATM
SCHEMBL29531707 0.78 NPC1 (0.69) NPC1RAB9AMEN1KMT2AATM
SCHEMBL29627559 0.74 ALDH1A1 (0.65) NPC1RAB9AMEN1KMT2AATM
SCHEMBL30682 0.74 ALDH1A1 (0.65) NPC1RAB9AMEN1KMT2AATM
SCHEMBL30096340 0.74 ALDH1A1 (0.65) NPC1RAB9AMEN1KMT2AATM
SCHEMBL2493869 0.74 ALDH1A1 (0.56) NPC1RAB9AMEN1KMT2AATM
SCHEMBL7686040 0.74 ALDH1A1 (0.49) NPC1RAB9AMEN1KMT2AATM
SCHEMBL31170 0.74 NPC1 (0.81) NPC1RAB9AMEN1KMT2AATM
SCHEMBL3307010 0.73 NPC1 (0.46) NPC1RAB9AMEN1KMT2AATM
SCHEMBL27365149 0.72 NPC1 (0.67) NPC1RAB9AMEN1KMT2AATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114867719-B Pyrrolidine and piperidine compounds 柳韩洋行 2024-06-25 CN disclosed
WO-2007146914-A1 GHRELIN MODULATING COMPOUNDS ELIXIR PHARMACEUTICALS, INC. (US) 2007-12-21 WO disclosed