SCHEMBL5324232

SCHEMBL5324232

Cc1ccc(N)cc1C1CCNCC1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 8/20 0.58
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
ALDH1A1 P00352 2/20 0.42
CASP1 P29466 2/20 0.41
SLC6A2 P23975 2/20 0.38
SLC6A4 P31645 2/20 0.38
SLC6A3 Q01959 1/20 0.38
HTR1A P08908 1/20 0.38
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
GABRA1 P14867 1/20 0.38
GABRB2 P47870 1/20 0.38
HRH4 Q9H3N8 1/20 0.38
MEN1 O00255 1/20 0.38
MAPT P10636 1/20 0.38
PKM P14618 1/20 0.38
ALOX15 P16050 1/20 0.38
KMT2A Q03164 1/20 0.38
TDP1 Q9NUW8 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18031194 0.87 ALDH1A1 (0.50) HTR2CCHRNB2CHRNA4ALDH1A1CASP1
SCHEMBL29533172 0.86 HTR2C (0.58) HTR2CCHRNB2CHRNA4ALDH1A1SLC6A2
SCHEMBL14320532 0.86 HTR2C (0.58) HTR2CCHRNB2CHRNA4ALDH1A1SLC6A2
Hydrochloric Acid SCHEMBL31406372 0.81 ALDH1A1 (0.45) HTR2CCHRNB2CHRNA4ALDH1A1CASP1
SCHEMBL17948231 0.81 HTR2C (0.61) HTR2CCHRNB2CHRNA4SLC6A2SLC6A4
SCHEMBL10893758 0.80 ALDH1A1 (0.43) HTR2CCHRNB2CHRNA4ALDH1A1CASP1
Hydrochloric Acid SCHEMBL4888125 0.80 HTR2C (0.62) HTR2CCHRNB2CHRNA4SLC6A2SLC6A4
SCHEMBL5321647 0.79 CCNT1 (0.47) HTR2CCHRNB2CHRNA4SLC6A2SLC6A4
SCHEMBL21725482 0.79 HTR2C (0.58) HTR2CSLC6A2SLC6A4SLC6A3HTR1A
SCHEMBL17774741 0.79 QDPR (0.51) HTR2CCHRNB2CHRNA4HTR1AHRH4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007114902-A2 ALKYLTHIOBENZYLPIPERIDINE COMPOUNDS H.LUNDBECK A/S (DK) 2007-10-11 WO disclosed