Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTH1R | Q03431 | 15/20 | 0.67 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5376690 | 0.88 | PTH1R (0.74) | PTH1R | |
| SCHEMBL5487298 | 0.88 | PTH1R (0.67) | PTH1RHTR1DHTR1B | |
| SCHEMBL5368169 | 0.86 | PTH1R (0.69) | PTH1RTAAR1ADRA1DADRA1AADRA1B | |
| SCHEMBL5358731 | 0.86 | PTH1R (0.53) | PTH1RHTR1DHTR1BMAOAMAOB | |
| SCHEMBL5344648 | 0.86 | PTH1R (0.51) | PTH1RHTR1DHTR1BMAOAMAOB | |
| SCHEMBL5367699 | 0.85 | PTH1R (0.76) | PTH1RHTR1DHTR1B | |
| SCHEMBL5363678 | 0.85 | PTH1R (0.56) | PTH1R | |
| SCHEMBL5356554 | 0.84 | PTH1R (0.67) | PTH1RMAOAMAOBNISCH | |
| SCHEMBL5363635 | 0.83 | PTH1R (0.82) | PTH1RHTR1DHTR1B | |
| SCHEMBL5323706 | 0.83 | PTH1R (0.56) | PTH1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135417-A1 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-11-29 | — | — | WO | disclosed |