Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTH1R | Q03431 | 4/20 | 0.51 |
| ▸ | NISCH | Q9Y2I1 | 6/20 | 0.39 |
| ▸ | HTR1D | P28221 | 3/20 | 0.38 |
| ▸ | HTR1B | P28222 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5324368 | 0.86 | PTH1R (0.67) | PTH1RNISCHHTR1DHTR1BMAOA | |
| SCHEMBL5350284 | 0.84 | PTH1R (0.39) | PTH1RMAOAMAOB | |
| SCHEMBL5376690 | 0.75 | PTH1R (0.74) | PTH1RCYP3A4KCNH2MCHR1 | |
| SCHEMBL5487298 | 0.74 | PTH1R (0.67) | PTH1RHTR1DHTR1B | |
| SCHEMBL5358731 | 0.74 | PTH1R (0.53) | PTH1RNISCHHTR1DHTR1BMAOA | |
| SCHEMBL5368169 | 0.72 | PTH1R (0.69) | PTH1RADRA1DADRA1AADRA1BTAAR1 | |
| SCHEMBL5352432 | 0.72 | PTH1R (0.33) | PTH1RMAOB | |
| SCHEMBL5363635 | 0.70 | PTH1R (0.82) | PTH1RHTR1DHTR1B | |
| SCHEMBL5367699 | 0.70 | PTH1R (0.76) | PTH1RHTR1DHTR1B | |
| SCHEMBL5362367 | 0.70 | PTH1R (0.84) | PTH1RHTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135417-A1 | BENZOTRIAZEPINONE DERIVATIVES | JAMES BLACK FOUNDATION (GB) | 2007-11-29 | — | — | WO | disclosed |