Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 4/20 | 0.57 |
| ▸ | GBA1 | P04062 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8250781 | 0.87 | HTT (0.54) | L3MBTL1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL12176908 | 0.86 | LMNA (0.60) | ALDH1A1GAAMAPTHTTMAPK1 | |
| SCHEMBL2896487 | 0.85 | ALDH1A1 (0.54) | L3MBTL1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL6970988 | 0.85 | FFAR1 (0.57) | L3MBTL1RAB9AALDH1A1MAPTHTT | |
| SCHEMBL25412945 | 0.85 | ALDH1A1 (0.54) | L3MBTL1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL25412633 | 0.84 | ALDH1A1 (0.63) | L3MBTL1ALDH1A1MAPTTSHRPOLB | |
| SCHEMBL3718777 | 0.84 | NR1I2 (0.62) | ALDH1A1GAAMAPTHTTMAPK1 | |
| SCHEMBL13929466 | 0.83 | HTT (0.51) | L3MBTL1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL12673467 | 0.83 | SIRT2 (0.61) | ALDH1A1GAAMAPTHTTMAPK1 | |
| SCHEMBL5323143 | 0.83 | NR1I2 (0.60) | ALDH1A1GAAMAPTHTTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007144379-A1 | BICYCLIC COMPOUNDS USEFUL AS CATHEPSIN S INBHIBITORS | MEDIVIR AB (SE) | 2007-12-21 | — | — | WO | disclosed |
| WO-2006064286-A1 | CATHEPSIN S INHIBITORS | MEDIVIR UK LTD (GB) | 2006-06-22 | — | — | WO | disclosed |