Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 2/20 | 0.37 |
| ▸ | PLAU | P00749 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27996263 | 0.92 | XDH (0.33) | TDP1LMNAMEN1KMT2ATSHR | |
| SCHEMBL938 | 0.92 | — | — | |
| SCHEMBL1066878 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL27975795 | 0.90 | — | — | |
| Charcoal, Activated SCHEMBL30986727 | 0.90 | — | — | |
| Piperidine SCHEMBL25237583 | 0.78 | MAPT (0.34) | ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL28301506 | 0.77 | ALDH1A1 (0.35) | TDP1LMNASRD5A2MEN1KMT2A | |
| Acridine SCHEMBL27629347 | 0.74 | ALDH1A1 (0.47) | TDP1MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13011421 | 0.74 | — | — | |
| Silver SCHEMBL5305985 | 0.71 | TDP1 (0.34) | TDP1LMNASRD5A2CASP6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007112922-A1 | TRIMERIC, WATER-SOLUBLE AMINOPYRAZOLE COMPOUNDS HAVING AN EFFECT AGAINST NEURODEGENERATIVE DISEASES | PHILIPPS-UNIVERSITÄT MARBURG (DE) | 2007-10-11 | — | — | WO | disclosed |