SCHEMBL5324725

SCHEMBL5324725

c1ccc2sc(-n3cccn3)nc2c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
NPC1 O15118 6/20 0.47
RAB9A P51151 6/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
HSD17B10 Q99714 2/20 0.46
TP53 P04637 1/20 0.46
MEN1 O00255 2/20 0.45
KMT2A Q03164 2/20 0.45
KAT2A Q92830 1/20 0.45
KAT2B Q92831 1/20 0.45
MAPK1 P28482 1/20 0.45
HPGD P15428 2/20 0.45
MAPT P10636 1/20 0.45
NPSR1 Q6W5P4 3/20 0.44
CYP1A2 P05177 1/20 0.44
POLB P06746 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
JAK1 P23458 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23360634 0.78 NPC1 (0.46) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL13198295 0.75 RAB9A (0.56) ALDH1A1NPC1RAB9ASMN1; SMN2TP53
SCHEMBL18741279 0.75 RAB9A (0.46) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL9465324 0.74 RAB9A (0.53) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL19961708 0.72 NPC1 (0.45) ALDH1A1NPC1RAB9ASMN1; SMN2MEN1
SCHEMBL4971498 0.71 JAK1 (0.43) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL2074140 0.71 HSD17B10 (0.51) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL27696527 0.71 NPC1 (0.46) NPC1RAB9ASMN1; SMN2MEN1KMT2A
Hydrochloric Acid SCHEMBL18320425 0.71 NPC1 (0.53) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10
SCHEMBL19587018 0.70 MAPK1 (0.43) ALDH1A1NPC1RAB9ASMN1; SMN2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017063966-A1 SUBSTITUTED 2-(1H-PYRAZOL-1-YL)-BENZOTHIAZOLE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-04-20 WO disclosed
WO-2017063966-A1 SUBSTITUTED 2-(1H-PYRAZOL-1-YL)-BENZOTHIAZOLE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2017-04-20 WO disclosed
WO-2016202759-A1 CYTOTOXIC SUBSTITUTED 2-(1 H-PYRAZOL-1 -YL)-1,3-BENZOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF CANCER BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-22 WO disclosed
WO-2016202759-A1 CYTOTOXIC SUBSTITUTED 2-(1 H-PYRAZOL-1 -YL)-1,3-BENZOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF CANCER BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-22 WO disclosed
WO-2016202759-A1 CYTOTOXIC SUBSTITUTED 2-(1 H-PYRAZOL-1 -YL)-1,3-BENZOTHIAZOLE COMPOUNDS FOR THE TREATMENT OF CANCER BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-22 WO disclosed
WO-2016202758-A1 SUBSTITUTED 2-(1H-PYRAZOL-1-YL)-1H-BENZIMIDAZOLE COMPOUNDS BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-12-22 WO disclosed
WO-2007129169-A2 COX- II INHIBITORS FOR IMPROVING REPRODUCTIVE SUCCESS IN A FEMALE ANIMAL PFIZER LIMITED (GB) 2007-11-15 WO disclosed