Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 13/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3743991 | 0.78 | PDE3B (0.39) | PDE3BPDE3APTGDR2DYRK1APLA2G2A | |
| SCHEMBL3743985 | 0.67 | HSD11B1 (0.41) | PDE3BPDE3APTGDR2DYRK1APLA2G2A | |
| SCHEMBL3744016 | 0.64 | RXRB (0.39) | DYRK1AMEN1KMT2A | |
| SCHEMBL3554796 | 0.60 | FFAR4 (0.41) | PDE3BPDE3APTGDR2P2RY12MEN1 | |
| SCHEMBL4698593 | 0.60 | PDE3B (0.42) | PDE3BPDE3APTGDR2P2RY12MEN1 | |
| SCHEMBL11720322 | 0.58 | HRH3 (0.57) | PTGDR2MEN1KMT2AFFAR4 | |
| SCHEMBL11727674 | 0.58 | HRH3 (0.56) | PTGDR2MEN1KMT2AFFAR4 | |
| SCHEMBL116455 | 0.57 | FFAR4 (0.62) | FFAR1FFAR4 | |
| SCHEMBL29700092 | 0.57 | FFAR4 (0.62) | FFAR1FFAR4 | |
| SCHEMBL11724117 | 0.57 | MEN1 (0.53) | PTGDR2MEN1KMT2AFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830840-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-09-12 | — | — | EP | claimed |
| WO-2006068991-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-06-29 | — | — | WO | claimed |