Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.36 |
| ▸ | SPR | P35270 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38666762 | 0.82 | MAP4K4 (0.53) | SUV39H2GPR119MAP4K4HDAC1CYP3A4 | |
| SCHEMBL38665917 | 0.82 | MAP4K4 (0.53) | SUV39H2GPR119MAP4K4HDAC1CYP3A4 | |
| SCHEMBL29418786 | 0.81 | GPR119 (0.48) | SUV39H2GPR119MAP4K4HDAC1SETD7 | |
| SCHEMBL25214652 | 0.81 | GPR119 (0.48) | SUV39H2GPR119MAP4K4HDAC1SETD7 | |
| SCHEMBL16707804 | 0.80 | GPR119 (0.42) | SUV39H2GPR119CYP3A4ALDH1A1MAPT | |
| SCHEMBL30045663 | 0.79 | SUV39H2 (0.48) | SUV39H2GPR119MAP4K4HDAC1SETD7 | |
| SCHEMBL23560874 | 0.79 | MAP4K4 (0.54) | SUV39H2GPR119MAP4K4HDAC1SETD7 | |
| SCHEMBL30005266 | 0.79 | SUV39H2 (0.51) | SUV39H2GPR119MAP4K4HDAC1NR1H2 | |
| SCHEMBL31173943 | 0.78 | SUV39H2 (0.49) | SUV39H2GPR119MAP4K4HDAC1NR1H2 | |
| SCHEMBL30419719 | 0.78 | SUV39H2 (0.49) | SUV39H2GPR119MAP4K4HDAC1NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135427-A1 | 1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS | ASTRAZENECA AB (SE) | 2007-11-29 | — | — | WO | disclosed |