Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5325388 | 1.00 | POLB (0.39) | POLBALDH1A1MAPTCYP2C19KDM4E | |
| SCHEMBL14625379 | 0.89 | ALDH1A1 (0.43) | POLBALDH1A1MAPTKDM4ESMN1; SMN2 | |
| SCHEMBL14625464 | 0.85 | CYP2C19 (0.43) | POLBALDH1A1MAPTCYP2C19KDM4E | |
| SCHEMBL14625355 | 0.83 | CYP3A4 (0.52) | ALDH1A1MAPTCYP2C19KMT2ACYP3A4 | |
| SCHEMBL14625068 | 0.80 | CYP3A4 (0.41) | ALDH1A1MAPTCYP2C19KDM4EMEN1 | |
| SCHEMBL5308646 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP2C19CYP3A4 | |
| SCHEMBL5308650 | 0.79 | ALDH1A1 (0.50) | ALDH1A1MAPTCYP2C19CYP3A4 | |
| SCHEMBL14624818 | 0.78 | ALDH1A1 (0.45) | ALDH1A1MAPTCYP2C19LMNAMEN1 | |
| SCHEMBL5330894 | 0.77 | ALDH1A1 (0.49) | POLBALDH1A1MAPTCYP2C19KDM4E | |
| SCHEMBL5307157 | 0.77 | MAPT (0.49) | ALDH1A1MAPTCYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007011910-A2 | CHIRAL AMINE-CATALYZED ASYMMETRIC ADDITION OF CARBON-CENTERED NUCLEOPHILES TO IMINES | TRUSTEES OF BOSTON UNIVERSITY (US) | 2007-01-25 | — | — | WO | disclosed |