Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | MC5R | P33032 | 5/20 | 0.41 |
| ▸ | MC4R | P32245 | 4/20 | 0.41 |
| ▸ | MC3R | P41968 | 4/20 | 0.41 |
| ▸ | MC1R | Q01726 | 1/20 | 0.41 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5324945 | 0.84 | HDAC1 (0.47) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL6038165 | 0.83 | HDAC1 (0.46) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5323568 | 0.82 | MPO (0.46) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL6038142 | 0.75 | HDAC1 (0.51) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5287183 | 0.73 | HDAC1 (0.48) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL6037892 | 0.72 | NAMPT (0.57) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL6038087 | 0.71 | HDAC1 (0.54) | HDAC1HDAC3HDAC4HDAC7HDAC2 | |
| SCHEMBL5320008 | 0.70 | SIRT1 (0.51) | TRPV1CDK4CCND1ACHE | |
| SCHEMBL6038067 | 0.70 | HTR1D (0.50) | TRPM8NAMPTHTR1D | |
| SCHEMBL6038096 | 0.68 | NAMPT (0.52) | HDAC1HDAC3HDAC4HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863804-A1 | INHIBITORS OF HISTONE DEACETYLASE | Methylgene, Inc. (CA) | 2007-12-12 | — | — | EP | claimed |
| WO-2006102760-A1 | INHIBITORS OF HISTONE DEACETYLASE | METHYLGENE INC. (CA) | 2006-10-05 | — | — | WO | claimed |