SCHEMBL5325529

SCHEMBL5325529

[O]C(=O)c1ncccc1C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 2/20 0.46
WNT3A P56704 2/20 0.46
CNR2 P34972 1/20 0.45
NFE2L2 Q16236 1/20 0.45
HCRTR1 O43613 1/20 0.43
HCRTR2 O43614 1/20 0.43
TLR7 Q9NYK1 2/20 0.42
TRPV1 Q8NER1 5/20 0.41
HSD11B1 P28845 1/20 0.41
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP3A4 P08684 1/20 0.41
MAPT P10636 1/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.41
BLM P54132 1/20 0.41
AGER Q15109 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
GAA P10253 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL286833 0.85 KDM4E (0.55) CTNNB1WNT3ACNR2NFE2L2HCRTR1
SCHEMBL3058108 0.83 CTNNB1 (0.45) CTNNB1WNT3ACNR2NFE2L2HCRTR1
Hydrochloric Acid SCHEMBL3058112 0.83 KDM4E (0.53) CTNNB1WNT3ACNR2NFE2L2HCRTR1
SCHEMBL1570557 0.83 CTNNB1 (0.45) CTNNB1WNT3ACNR2NFE2L2HCRTR1
SCHEMBL1859913 0.83 NFE2L2 (0.47) CTNNB1WNT3ACNR2NFE2L2HCRTR1
Hydrochloric Acid SCHEMBL25226224 0.81 CTNNB1 (0.44) CTNNB1WNT3ACNR2NFE2L2HCRTR1
SCHEMBL31570640 0.80 CTNNB1 (0.43) CTNNB1WNT3ACNR2NFE2L2HCRTR1
SCHEMBL11919358 0.80 NFE2L2 (0.45) CTNNB1WNT3ACNR2NFE2L2HCRTR1
SCHEMBL4366167 0.79 CTNNB1 (0.51) CTNNB1WNT3ACNR2NFE2L2HCRTR1
SCHEMBL2439027 0.79 CTNNB1 (0.42) CTNNB1WNT3ACNR2NFE2L2HCRTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007120012-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2007-10-25 WO claimed
WO-2007120012-A1 NOVEL COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS VANILLOID RECEPTOR ANTAGONIST; AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AMOREPACIFIC CORPORATION (KR) 2007-10-25 WO disclosed