SCHEMBL4366167

SCHEMBL4366167

O=C(CBr)c1ncccc1C(F)(F)F

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTNNB1 P35222 2/20 0.51
WNT3A P56704 2/20 0.51
PTPN1 P18031 1/20 0.42
GSK3B P49841 1/20 0.42
TLR7 Q9NYK1 2/20 0.41
CNR2 P34972 1/20 0.41
NFE2L2 Q16236 1/20 0.41
HCRTR1 O43613 1/20 0.40
HCRTR2 O43614 1/20 0.40
RBP4 P02753 1/20 0.39
TRPV1 Q8NER1 3/20 0.38
HSD11B1 P28845 1/20 0.38
ADORA2A P29274 1/20 0.38
ADORA1 P30542 1/20 0.38
GAA P10253 1/20 0.37
DHODH Q02127 1/20 0.37
HDAC6 Q9UBN7 1/20 0.37
KDM4E B2RXH2 2/20 0.37
MAPT P10636 2/20 0.37
ALDH1A1 P00352 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29365642 1.00 CTNNB1 (0.51) CTNNB1WNT3APTPN1GSK3BTLR7
Bromide SCHEMBL4353378 0.98 CTNNB1 (0.50) CTNNB1WNT3APTPN1GSK3BTLR7
SCHEMBL11920844 0.83 CTNNB1 (0.51) CTNNB1WNT3ATLR7CNR2NFE2L2
Hydrochloric Acid SCHEMBL23354263 0.82 CTNNB1 (0.50) CTNNB1WNT3ATLR7CNR2NFE2L2
Hydrochloric Acid SCHEMBL29978860 0.82 CTNNB1 (0.50) CTNNB1WNT3ATLR7CNR2NFE2L2
Hydrochloric Acid SCHEMBL1981601 0.82 CTNNB1 (0.50) CTNNB1WNT3ATLR7CNR2NFE2L2
SCHEMBL15988700 0.81 CTNNB1 (0.58) CTNNB1WNT3ACNR2NFE2L2HCRTR1
SCHEMBL5325529 0.79 CTNNB1 (0.46) CTNNB1WNT3ATLR7CNR2NFE2L2
SCHEMBL286833 0.79 KDM4E (0.55) CTNNB1WNT3ATLR7CNR2NFE2L2
SCHEMBL1981639 0.78 CTNNB1 (0.47) CTNNB1WNT3ATLR7CNR2NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109671-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME CURASEN THERAPEUTICS INC (US) 2026-04-23 US disclosed
US-12448352-B2 Beta adrenergic agonist and methods of using the same CURASEN THERAPEUTICS, INC. (US) 2025-10-21 US disclosed
US-20220169612-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME CURASEN THERAPEUTICS, INC. 2022-06-02 US disclosed
EP-3946329-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME Curasen Therapeutics, Inc. (US) 2022-02-09 EP disclosed
CN-114007615-A Beta adrenergic agonists and methods of use thereof 库拉森疗法公司 2022-02-01 CN disclosed
US-20210371380-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME CURASEN THERAPEUTICS, INC. 2021-12-02 US disclosed
US-11040944-B2 Beta adrenergic agonist and methods of using the same CURASEN THERAPEUTICS, INC. (US) 2021-06-22 US disclosed
US-10947196-B2 Beta adrenergic agonist and methods of using the same CURASEN THERAPEUTICS, INC. (US) 2021-03-16 US disclosed
US-20200308114-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME CURASEN THERAPEUTICS, INC. 2020-10-01 US disclosed
US-20200308115-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME CURASEN THERAPEUTICS, INC. 2020-10-01 US disclosed
US-20090286767-A1 SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES NEUROGEN CORPORATION (US) 2009-11-19 US disclosed
US-20090286767-A1 SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES NEUROGEN CORPORATION (US) 2009-11-19 US disclosed
US-20090286767-A1 SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES NEUROGEN CORPORATION (US) 2009-11-19 US disclosed
US-7488740-B2 Substituted quinolin-4-ylamine analogues NEUROGEN CORPORATION (US) 2009-02-10 US disclosed
US-7488740-B2 Substituted quinolin-4-ylamine analogues NEUROGEN CORPORATION (US) 2009-02-10 US disclosed
US-7488740-B2 Substituted quinolin-4-ylamine analogues NEUROGEN CORPORATION (US) 2009-02-10 US disclosed
US-20060154930-A1 Substituted amino heterocycles as vr-1 antagonists for treating pain MERCK SHARP & DOHME LTD. (GB) 2006-07-13 US disclosed
EP-1644372-A2 SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES NEUROGEN CORPORATION (US) 2006-04-12 EP disclosed
US-20050070547-A1 Substituted quinolin-4-ylamine analogues NEUROGEN CORPORATION 2005-03-31 US disclosed
WO-2005007652-A2 SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES NEUROGEN CORPORATION (US) 2005-01-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060154930-A1 Substituted amino heterocycles as vr-1 antagonists for treating pain OPRL1, OPRM1, OPRK1 CTNNB1 545/4885WNT3A 579/4885PTPN1 2002/4885
US-20200308114-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME ADRB2, ADRB1, ADRA2C CTNNB1 1580/4885WNT3A 4005/4885PTPN1 4026/4885
US-20200308115-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME ADRB2, ADRB1, ADRA2C CTNNB1 1580/4885WNT3A 4005/4885PTPN1 4026/4885
US-10947196-B2 Beta adrenergic agonist and methods of using the same ADRB2, ADRB1, ADRA2C CTNNB1 1580/4885WNT3A 4005/4885PTPN1 4026/4885
US-12448352-B2 Beta adrenergic agonist and methods of using the same ADRA2B, ADRB2, ADRB1 CTNNB1 1186/4885WNT3A 3745/4885PTPN1 2572/4885
US-20210371380-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME ADRB2, ADRB1, ADRA2C CTNNB1 1580/4885WNT3A 4005/4885PTPN1 4026/4885
US-20090286767-A1 SUBSTITUTED QUINOLIN-4-YLAMINE ANALOGUES PIGS, HRH4, GPR52 CTNNB1 3462/4885WNT3A 2667/4885PTPN1 2836/4885
US-20050070547-A1 Substituted quinolin-4-ylamine analogues PIGS, HRH4, GPR52 CTNNB1 3475/4885WNT3A 2651/4885PTPN1 2788/4885
US-11040944-B2 Beta adrenergic agonist and methods of using the same ADRB2, ADRB1, ADRA2C CTNNB1 1580/4885WNT3A 4005/4885PTPN1 4026/4885
US-20260109671-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME ADRB2, ADRB1, ADRA2C CTNNB1 242/4885WNT3A 566/4885PTPN1 1990/4885
US-20220169612-A1 BETA ADRENERGIC AGONIST AND METHODS OF USING THE SAME ADRA2B, ADRB2, ADRB1 CTNNB1 1186/4885WNT3A 3745/4885PTPN1 2572/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.