SCHEMBL5325702

SCHEMBL5325702

C=CCOC(=O)C(Br)c1ccccc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.51
CES2 O00748 2/20 0.50
CES1 P23141 2/20 0.50
CYP2C19 P33261 1/20 0.46
ALDH1A1 P00352 4/20 0.45
TSHR P16473 1/20 0.45
HSD17B10 Q99714 1/20 0.45
PKM P14618 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
NPSR1 Q6W5P4 2/20 0.42
CASP1 P29466 3/20 0.40
RHOA P61586 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP2D6 P10635 1/20 0.39
KMT2A Q03164 2/20 0.38
KDM4E B2RXH2 1/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
GAA P10253 1/20 0.38
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14392088 1.00 CYP3A4 (0.51) CYP3A4CES2CES1CYP2C19ALDH1A1
SCHEMBL7878160 0.84 CYP3A4 (0.53) CYP3A4CES2CES1CYP2C19ALDH1A1
SCHEMBL5356165 0.83 MEN1 (0.46) CYP3A4CYP2C19ALDH1A1TSHRHSD17B10
SCHEMBL2879779 0.82 CYP3A4 (0.59) CYP3A4CYP2C19ALDH1A1TSHRHSD17B10
SCHEMBL9230354 0.82 CYP3A4 (0.55) CYP3A4CYP2C19ALDH1A1TSHRHSD17B10
SCHEMBL6681242 0.81 CYP3A4 (0.53) CYP3A4CES2CES1CYP2C19ALDH1A1
SCHEMBL6681237 0.81 CYP3A4 (0.53) CYP3A4CES2CES1CYP2C19ALDH1A1
SCHEMBL10676559 0.79 CYP3A4 (0.51) CYP3A4CYP2C19ALDH1A1TSHRHSD17B10
SCHEMBL2879781 0.79 CYP3A4 (0.56) CYP3A4CYP2C19ALDH1A1TSHRHSD17B10
SCHEMBL10590388 0.79 CYP3A4 (0.51) CYP3A4CYP2C19ALDH1A1TSHRHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007124544-A1 INTEGRASE INHIBITORS - 1 AVEXA LIMITED (AU) 2007-11-08 WO disclosed
WO-2007124545-A1 INTEGRASE INHIBITORS - 2 AVEXA LIMITED (AU) 2007-11-08 WO disclosed
WO-2007124545-A1 INTEGRASE INHIBITORS - 2 AVEXA LIMITED (AU) 2007-11-08 WO disclosed
EP-0617001-B1 Phenoxyphenylacetic acid derivatives MERCK & CO INC (US) 2000-01-26 EP disclosed
US-5767310-A Phenoxyphenylacetic acid derivatives MERCK & CO., INC. (US) 1998-06-16 US disclosed
EP-0774965-A4 PHENOXYPHENYLACETIC ACID DERIVATIVES MERCK & CO INC (US) 1997-10-29 EP disclosed
US-5668176-A ENDOTHELIN ANTAGONIST MERCK & CO. INC. (US) 1997-09-16 US disclosed
EP-0774965-A1 PHENOXYPHENYLACETIC ACID DERIVATIVES MERCK & CO. INC. (US) 1997-05-28 EP disclosed
US-5565485-A TREATING CARDIOVASCULAR DISORDERS MERCK & CO., INC. (US) 1996-10-15 US disclosed
WO-1996009818-A1 ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS MERCK & CO., INC. (US) 1996-04-04 WO disclosed
WO-1996004905-A1 PHENOXYPHENYLACETIC ACID DERIVATIVES MERCK & CO., INC. (US) 1996-02-22 WO disclosed
WO-1994021590-A1 PHENOXYPHENYLACETIC ACID DERIVATIVES MERCK & CO., INC. (US) 1994-09-29 WO disclosed
EP-0617001-A1 Phenoxyphenylacetic acid derivatives MERCK & CO. INC. (US) 1994-09-28 EP disclosed