SCHEMBL5327906

SCHEMBL5327906

Fc1ccc(C=C(Br)Br)c(NCc2ccccc2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
RAB9A P51151 1/20 0.41
HDAC1 Q13547 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
LMNA P02545 1/20 0.39
GAA P10253 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
PDE5A O76074 4/20 0.39
PLA2G1B P04054 1/20 0.39
ATG4B Q9Y4P1 1/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.39
SHMT2 P34897 1/20 0.38
KMT2A Q03164 1/20 0.38
IDO1 P14902 1/20 0.38
KCNH3 Q9ULD8 1/20 0.38
ALDH1A1 P00352 1/20 0.37
HDAC4 P56524 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4894540 0.82 HSD17B10 (0.53) HSD17B10L3MBTL1MAPTKMT2AIDO1
SCHEMBL1147662 0.81 HSD17B10 (0.45) HSD17B10SMN1; SMN2RAB9AHDAC1HDAC8
SCHEMBL5322842 0.77 CA1 (0.54) SMN1; SMN2HDAC1HDAC8HDAC6LMNA
SCHEMBL11512276 0.75 HDAC1 (0.59) HSD17B10SMN1; SMN2RAB9AHDAC1HDAC8
SCHEMBL12871405 0.72 HDAC8 (0.56) HSD17B10SMN1; SMN2HDAC1HDAC8HDAC6
SCHEMBL11964451 0.72 HDAC3 (0.49) HSD17B10SMN1; SMN2HDAC1HDAC8HDAC6
SCHEMBL1147582 0.72 KDM4C (0.56) HSD17B10HDAC1HDAC8HDAC6GAA
SCHEMBL5203429 0.72 SHMT2 (0.56) HSD17B10SMN1; SMN2RAB9AHDAC1HDAC8
SCHEMBL23227889 0.71 ALDH1A1 (0.48) HSD17B10SMN1; SMN2HDAC1HDAC8HDAC6
SCHEMBL5327175 0.70 MEN1 (0.48) RAB9AHDAC6LMNAGAAL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007134421-A1 2-VINYL INDOLES, PYRIDO AND AZEPINO INDOLE DERIVATIVES, 2-ALKYNYL INDOLES, 2-ALKYNYL BENZO[b]FURANS, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF LAUTENS MARK (CA) 2007-11-29 WO disclosed
WO-2007134421-A1 2-VINYL INDOLES, PYRIDO AND AZEPINO INDOLE DERIVATIVES, 2-ALKYNYL INDOLES, 2-ALKYNYL BENZO[b]FURANS, THEIR PRECURSORS AND NOVEL PROCESSES FOR THE PREPARATION THEREOF LAUTENS MARK (CA) 2007-11-29 WO disclosed