Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 13/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 5/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3552134 | 0.99 | HSD11B1 (0.42) | HSD11B1DPP4DPP8DPP9ALDH1A1 | |
| SCHEMBL5300506 | 0.92 | DPP4 (0.37) | HSD11B1DPP4DPP8DPP9ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3551834 | 0.91 | DPP4 (0.36) | HSD11B1DPP4DPP8DPP9ALDH1A1 | |
| SCHEMBL3552196 | 0.77 | HSD11B1 (0.35) | HSD11B1ALDH1A1HPGDKMT2AUSP2 | |
| SCHEMBL3549630 | 0.77 | HSD11B1 (0.35) | HSD11B1 | |
| SCHEMBL3548754 | 0.77 | CNR1 (0.40) | HSD11B1 | |
| SCHEMBL3555731 | 0.76 | CDC7 (0.46) | HSD11B1DPP4DPP8ALDH1A1HPGD | |
| SCHEMBL3551713 | 0.75 | CNR1 (0.39) | HSD11B1ALDH1A1KDM4E | |
| SCHEMBL3547208 | 0.75 | ALDH1A1 (0.40) | ALDH1A1 | |
| SCHEMBL3549304 | 0.75 | SRD5A2 (0.45) | HSD11B1ALDH1A1HPGDKMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833812-A1 | N-[(4, 5-DIPHENYL-3-ALKYL-2-THIENYL) METHYL]AMINE (AMIDE, SULFONAMIDE, CARBAMATE AND UREA) DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS | Sanofi-Aventis (FR) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006070106-A1 | N-[(4, 5-DIPHENYL-3-ALKYL-2-THIENYL) METHYL] AMINE (AMIDE, SULFONAMIDE, CARBAMATE AND UREA) DERIVATIVES AS CANNABINOID CB1 RECEPTOR ANTAGONISTS | SANOFI-AVENTIS (FR) | 2006-07-06 | — | — | WO | disclosed |