Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.47 |
| ▸ | RBP4 | P02753 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5328497 | 1.00 | EPHX2 (0.64) | EPHX2HSD11B1RBP4GAAMAPT | |
| SCHEMBL2418788 | 0.84 | EPHX2 (0.55) | EPHX2HSD11B1RBP4GAAMAPT | |
| SCHEMBL1457210 | 0.82 | EPHX2 (0.66) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL1734757 | 0.82 | EPHX2 (0.66) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL3630668 | 0.82 | EPHX2 (0.66) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL233710 | 0.79 | EPHX2 (1.00) | EPHX2HSD11B1GAAMAPTTSHR | |
| Hydrochloric Acid SCHEMBL10319192 | 0.77 | EPHX2 (0.97) | EPHX2HSD11B1GAAMAPTTSHR | |
| Piperazine SCHEMBL5324447 | 0.77 | EPHX2 (0.97) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL5356587 | 0.74 | EPHX2 (0.89) | EPHX2HSD11B1GAAMAPTTSHR | |
| SCHEMBL14973800 | 0.73 | EPHX2 (0.59) | EPHX2HSD11B1RBP4GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007135427-A1 | 1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS | ASTRAZENECA AB (SE) | 2007-11-29 | — | — | WO | disclosed |
| WO-2007135427-A1 | 1,4-DISUBSTITUTED PIPERAZINE AND 1,4-DISUBSTITUTED AZEPANE AS 11 -BETA-HYDROXYSTEROID DEHYDROGENASE 1 INHIBITORS | ASTRAZENECA AB (SE) | 2007-11-29 | — | — | WO | disclosed |