Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5326569 | 0.87 | MAPK8 (0.53) | MAPK8MAPK9HDAC6THRBPGR | |
| SCHEMBL5332024 | 0.86 | SMN1; SMN2 (0.43) | MAPK8MAPK9HDAC6THRBPGR | |
| SCHEMBL5331602 | 0.81 | PGR (0.46) | MAPK8MAPK9THRBPGRRXFP1 | |
| SCHEMBL5334125 | 0.79 | KMT2A (0.43) | PGRRXFP1SMN1; SMN2MAPTPKM | |
| SCHEMBL5327489 | 0.79 | SMN1; SMN2 (0.40) | MAPK8MAPK9THRBRXFP1SMN1; SMN2 | |
| SCHEMBL5332658 | 0.78 | SMN1; SMN2 (0.39) | MAPK8MAPK9THRBRXFP1SMN1; SMN2 | |
| SCHEMBL5333099 | 0.69 | KDM4E (0.59) | RXFP1SMN1; SMN2LMNAMAPTPKM | |
| SCHEMBL3306391 | 0.66 | RXFP1 (0.43) | MAPK8MAPK9THRBPGRRXFP1 | |
| SCHEMBL5333721 | 0.64 | SMN1; SMN2 (0.47) | RXFP1SMN1; SMN2MAPTPKMKMT2A | |
| SCHEMBL5331459 | 0.61 | PGR (0.55) | MAPK8MAPK9PGRRXFP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007028789-A1 | QUINAZOLINE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | claimed |
| WO-2007028789-A1 | QUINAZOLINE DERIVATIVES AS ANTIVIRAL AGENTS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2007-03-15 | — | — | WO | disclosed |