Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 13/20 | 0.53 |
| ▸ | MME | P08473 | 1/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5306138 | 0.91 | KDM4E (0.49) | DHODHHCAR2MMETDP1GAA | |
| SCHEMBL5306769 | 0.90 | HCAR2 (0.54) | HCAR2CYP2C8CYP2C9LTB4R | |
| SCHEMBL5305006 | 0.85 | DHODH (0.53) | DHODHHCAR2MMECYP2C8CYP2C9 | |
| SCHEMBL5062205 | 0.83 | HCAR2 (0.64) | HCAR2CYP2C8CYP2C9LTB4R | |
| SCHEMBL5300869 | 0.82 | HCAR2 (0.62) | HCAR2CYP2C8CYP2C9ALDH1A1 | |
| SCHEMBL5302935 | 0.82 | HCAR2 (0.76) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL14609869 | 0.82 | HCAR2 (0.57) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL5294627 | 0.82 | HCAR2 (0.55) | HCAR2CYP2C8CYP2C9 | |
| SCHEMBL5302041 | 0.82 | DHODH (0.52) | DHODHHCAR2MMETDP1GAA | |
| SCHEMBL5307245 | 0.82 | KDM4E (0.52) | HCAR2GAALTB4RALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | claimed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |