Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | MMP8 | P22894 | 2/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18009989 | 0.83 | GAA (0.57) | GAAMMP8PIN1NPC1MEN1 | |
| SCHEMBL2960871 | 0.82 | CA12 (0.62) | GAAMMP8PIN1NPC1MEN1 | |
| SCHEMBL27631537 | 0.82 | GAA (0.54) | GAAMMP8PIN1NPC1MEN1 | |
| SCHEMBL8031605 | 0.81 | ELANE (0.53) | GAAMMP8PIN1NPC1MEN1 | |
| SCHEMBL6026706 | 0.81 | ELANE (0.53) | GAAMMP8PIN1NPC1MEN1 | |
| SCHEMBL655368 | 0.81 | ELANE (0.53) | GAAMMP8PIN1NPC1MEN1 | |
| Hydrochloric Acid SCHEMBL1171032 | 0.79 | ELANE (0.52) | GAAMMP8PIN1NPC1MEN1 | |
| SCHEMBL28428934 | 0.79 | GAA (0.51) | GAAMMP8PIN1NPC1MEN1 | |
| SCHEMBL10952879 | 0.78 | GAA (0.50) | GAAMMP8PIN1NPC1MEN1 | |
| SCHEMBL9338686 | 0.78 | CA12 (0.54) | GAAMMP8PIN1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007008942-A2 | PHENYLAMINO-ACETIC ACID [1-(PYRIDIN-4-YL)-METHYLIDENE]-HYDRAZIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF G PROTEIN-COUPLED RECEPTOR KINASES FOR THE TREATMENT OF EYE DISEASES | AERIE PHARMACEUTICALS, INC. (US) | 2007-01-18 | — | — | WO | disclosed |