SCHEMBL532939

SCHEMBL532939

Cc1cc(C)c(N2CCCC2)c(C)c1NS(=O)(=O)c1ccccc1Br

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EDNRA P25101 2/20 0.43
EDNRB P24530 1/20 0.41
BRD4 O60885 1/20 0.41
MAPT P10636 3/20 0.40
KMT2A Q03164 3/20 0.40
ALDH1A1 P00352 1/20 0.40
GAA P10253 1/20 0.40
GFER P55789 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
JAK2 O60674 1/20 0.39
KLK7 P49862 1/20 0.38
PIK3CA P42336 1/20 0.37
HTR6 P50406 1/20 0.37
POLB P06746 4/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
HIF1A Q16665 1/20 0.36
MEN1 O00255 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL532980 0.89 JAK2 (0.48) EDNRABRD4MAPTKMT2AALDH1A1
SCHEMBL532038 0.85 ALDH1A1 (0.54) EDNRAEDNRBBRD4MAPTKMT2A
SCHEMBL534052 0.85 MEN1 (0.47) EDNRAEDNRBBRD4MAPTKMT2A
SCHEMBL533083 0.83 EDNRA (0.46) EDNRAEDNRBMAPTALDH1A1JAK2
SCHEMBL533550 0.83 HCRTR1 (0.47) EDNRAEDNRBMAPTKMT2AHTR6
SCHEMBL532999 0.82 TP53 (0.48) BRD4KMT2AALDH1A1MEN1
SCHEMBL533512 0.82 SLC22A12 (0.44) MAPTKMT2AALDH1A1TDP1JAK2
SCHEMBL532998 0.82 JAK2 (0.37) MAPTKMT2AALDH1A1GAAGFER
SCHEMBL532776 0.82 FFAR4 (0.54) MAPTKMT2AALDH1A1GAATDP1
SCHEMBL3982592 0.82 MEN1 (0.46) EDNRAEDNRBMAPTKMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2415760-A2 CCR-9 antagonists ENCYSIVE PHARMACEUTICALS, INC. (US) 2012-02-08 EP disclosed
US-7319111-B2 Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists ENCYSIVE PHARMACEUTICALS, INC. (US) 2008-01-15 US disclosed
US-7319111-B2 Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists ENCYSIVE PHARMACEUTICALS, INC. (US) 2008-01-15 US disclosed
US-7319111-B2 Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists ENCYSIVE PHARMACEUTICALS, INC. (US) 2008-01-15 US disclosed