Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.46 |
| ▸ | EDNRB | P24530 | 6/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532980 | 0.87 | JAK2 (0.48) | EDNRAJAK2LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL532038 | 0.83 | ALDH1A1 (0.54) | EDNRAEDNRBJAK2LMNAALDH1A1 | |
| SCHEMBL534052 | 0.83 | MEN1 (0.47) | EDNRAEDNRBJAK2LMNAALDH1A1 | |
| SCHEMBL532939 | 0.83 | EDNRA (0.43) | EDNRAEDNRBJAK2ALDH1A1L3MBTL1 | |
| SCHEMBL534077 | 0.83 | TSHR (0.47) | EDNRAEDNRBLMNAALDH1A1L3MBTL1 | |
| SCHEMBL8314837 | 0.83 | MAPT (0.39) | JAK2LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL532776 | 0.83 | FFAR4 (0.54) | LMNAALDH1A1L3MBTL1MAPTPOLB | |
| SCHEMBL533578 | 0.82 | ACLY (0.43) | JAK2MAPTPOLB | |
| SCHEMBL533550 | 0.81 | HCRTR1 (0.47) | EDNRAEDNRBHCRTR1MAPT | |
| SCHEMBL533016 | 0.81 | ALPL (0.49) | ALDH1A1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415760-A2 | CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2012-02-08 | — | — | EP | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319111-B2 | Phenylenediamine Urotensin-II receptor antagonists and CCR-9 antagonists | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2008-01-15 | — | — | US | disclosed |