Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.39 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10451789 | 0.83 | MEN1 (0.43) | HTR2ATP53IDO1HTR2CHTR2B | |
| SCHEMBL4604208 | 0.83 | KMT2A (0.48) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL18482277 | 0.82 | HTR2A (0.41) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL25236513 | 0.81 | HTR2A (0.42) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL4331373 | 0.79 | HTR2A (0.45) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL13908021 | 0.79 | HTR2A (0.41) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL140474 | 0.79 | HTR2A (0.45) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL269324 | 0.79 | HTR2A (0.41) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL134961 | 0.79 | TP53 (0.41) | HTR2ATP53HTR1AHTR7HTR6 | |
| SCHEMBL17552702 | 0.79 | HTR2A (0.41) | HTR2ATP53HTR1AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116943570-A | 2-fluoro-4-chloro trichlorobenzyl chlorination reaction device | 阜新金特莱氟化学有限责任公司 | 2023-10-27 | — | — | CN | claimed |
| EP-4673447-A1 | [1,3]THIAZOLO[4,5-D]-PYRIMIDIN-7-ONES AS INHIBITORS OF NOX4 | Boehringer Ingelheim International GmbH (DE) | 2026-01-07 | — | — | EP | disclosed |
| CN-113493442-B | Pyrrolidone derivative as glucokinase activator and preparation method and application thereof | 天津药物研究院有限公司 | 2024-11-08 | — | — | CN | disclosed |
| US-20240327429-A1 | [1,3]Thiazolo[4,5-d]-pyrimidon-7-ones as inhibitors of NOX4 | BOEHRINGER INGELHEIM INT (DE) | 2024-10-03 | — | — | US | disclosed |
| WO-2024180018-A1 | [1,3]THIAZOLO[4,5-D]-PYRIMIDIN-7-ONES AS INHIBITORS OF NOX4 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2024-09-06 | — | — | WO | disclosed |
| CN-116943570-A | 2-fluoro-4-chloro trichlorobenzyl chlorination reaction device | 阜新金特莱氟化学有限责任公司 | 2023-10-27 | — | — | CN | disclosed |
| CN-116943570-A | 2-fluoro-4-chloro trichlorobenzyl chlorination reaction device | 阜新金特莱氟化学有限责任公司 | 2023-10-27 | — | — | CN | disclosed |
| US-20230165846-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2023-06-01 | — | — | US | disclosed |
| US-20230165846-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2023-06-01 | — | — | US | disclosed |
| US-20230165846-A1 | HETEROCYCLIC GLP-1 AGONISTS | GASHERBRUM BIO, INC. | 2023-06-01 | — | — | US | disclosed |
| CN-1198742-A | Pyrimidin-4-one derivatives, their use as herbicides, intermediates for their production and process for producing these compounds | SUMITOMO CHEMICAL CO (JP) | 1998-11-11 | — | — | CN | disclosed |
| EP-0850229-A1 | PYRIMIDIN-4-ONE DERIVATIVES, THEIR USE AS HERBICIDES, INTERMEDIATES FOR THEIR PRODUCTION AND PROCESSES FOR PRODUCING THESE COMPOUNDS | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997006150-A1 | PYRIMIDIN-4-ONE DERIVATIVES, THEIR USE AS HERBICIDES, INTERMEDIATES FOR THEIR PRODUCTION AND PROCESSES FOR PRODUCING THESE COMPOUNDS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-02-20 | — | — | WO | disclosed |
| US-4910323-A | Chlorination using n-chlorosuccinimide | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1990-03-20 | — | — | US | disclosed |
| US-4847414-A | INTERMEDIATES FOR ANTIDEPRESSANTS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0077536-B1 | 2'-SUBSTITUTED-SPIRO(BENZOFURAN-2(3H),1'-CYCLOALKANES), A PROCESS FOR PREPARING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SUCH COMPOUNDS AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-07-16 | — | — | EP | disclosed |
| US-4594435-A | ANTIDEPRESSANTS; ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1986-06-10 | — | — | US | disclosed |
| US-4517311-A | 2'-Substituted-spiro[benzofuran-2(3H),1'-cycloalkanes] and their analgesic and anti-depressant compositions | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-05-14 | — | — | US | disclosed |
| US-4404221-A | ANALGESICS AND ATNIDEPRESSANTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1983-09-13 | — | — | US | disclosed |
| EP-0077536-A2 | 2'-Substituted-spiro(benzofuran-2(3H),1'-cycloalkanes), a process for preparing same, pharmaceutical compositions containing such compounds and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1983-04-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240327429-A1 | [1,3]Thiazolo[4,5-d]-pyrimidon-7-ones as inhibitors of NOX4 | NOX4, NOX1, NOX5 | HTR2A 4151/4885TP53 2824/4885HTR1A 3693/4885 |
| US-20230165846-A1 | HETEROCYCLIC GLP-1 AGONISTS | GLP1R, GIPR, GCGR | HTR2A 169/4885TP53 4121/4885HTR1A 63/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.