Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17220642 | 0.85 | MAPT (0.43) | POLBL3MBTL1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL7454582 | 0.83 | MAPT (0.46) | POLBL3MBTL1KDM4EGAARAB9A | |
| SCHEMBL7454587 | 0.83 | HDAC1 (0.47) | POLBL3MBTL1KDM4EGAARAB9A | |
| SCHEMBL7258138 | 0.82 | HDAC1 (0.43) | POLBL3MBTL1KDM4EGAARAB9A | |
| SCHEMBL9373680 | 0.81 | KDM4E (0.54) | POLBKDM4EGAALMNACCR1 | |
| SCHEMBL18622117 | 0.81 | ALDH1A1 (0.49) | POLBL3MBTL1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL17681591 | 0.81 | HDAC1 (0.42) | POLBL3MBTL1KDM4EGAARAB9A | |
| SCHEMBL17230172 | 0.79 | KCNQ4 (0.47) | POLBL3MBTL1LMNASMN1; SMN2MAPT | |
| SCHEMBL8955980 | 0.77 | SMN1; SMN2 (0.55) | POLBL3MBTL1KDM4EGAALMNA | |
| SCHEMBL30748254 | 0.77 | SMN1; SMN2 (0.55) | POLBL3MBTL1KDM4EGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |
| WO-2007014054-A2 | BENZENESULFONAMIDE INHIBITOR OF CCR2 CHEMOKINE RECEPTOR | GLAXO GROUP LIMTED (GB) | 2007-02-01 | — | — | WO | disclosed |