SCHEMBL7258138

SCHEMBL7258138

CC(=O)NCc1ccc(F)cc1NC(C)=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.43
MTNR1A P48039 2/20 0.42
MTNR1B P49286 2/20 0.42
NOTUM Q6P988 1/20 0.42
TP53 P04637 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
MAPT P10636 1/20 0.41
POLB P06746 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
GAA P10253 2/20 0.40
P2RX7 Q99572 1/20 0.40
BDKRB1 P46663 1/20 0.40
KDM4E B2RXH2 2/20 0.40
RAB9A P51151 2/20 0.40
STAT1 P42224 1/20 0.40
CCNA2 P20248 1/20 0.40
CDK2 P24941 1/20 0.40
CCNA1 P78396 1/20 0.40
HDAC3 O15379 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5330388 0.82 POLB (0.48) HDAC1TP53RXFP1SMN1; SMN2MAPT
SCHEMBL7454582 0.82 MAPT (0.46) HDAC1SMN1; SMN2MAPTPOLBL3MBTL1
SCHEMBL7454587 0.82 HDAC1 (0.47) HDAC1SMN1; SMN2MAPTPOLBL3MBTL1
SCHEMBL5315312 0.81 P2RX7 (0.52) MTNR1AMTNR1BNOTUMP2RX7BDKRB1
SCHEMBL16318517 0.81 SETDB1 (0.51) HDAC1MTNR1AMTNR1BRXFP1SMN1; SMN2
SCHEMBL17681591 0.79 HDAC1 (0.42) HDAC1SMN1; SMN2MAPTPOLBL3MBTL1
SCHEMBL2831744 0.79 P2RX7 (0.56) TP53MAPTP2RX7LMNA
SCHEMBL4329523 0.78 CNR1 (0.45) MTNR1AMTNR1BNOTUMMAPTRAB9A
SCHEMBL13537179 0.77 MTNR1A (0.43) MTNR1AMTNR1BNOTUMP2RX7RAB9A
SCHEMBL20738728 0.76 HDAC3 (0.54) HDAC1MTNR1AMTNR1BSMN1; SMN2BDKRB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2003077857-A2 N-(SUBSTITUTED BENZYL)-8-HYDROXY-1,6-NAPHTHYRIDINE-7- CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS MERCK & CO., INC. (US) 2003-09-25 WO disclosed