Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.33 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | RBP4 | P02753 | 1/20 | 0.35 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR7 | P34969 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | SCD | O00767 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535333 | 0.96 | MEN1 (0.40) | MEN1KMT2ARAB9APDE4APDE4B | |
| Hydrochloric Acid SCHEMBL4526384 | 0.95 | MEN1 (0.39) | MEN1KMT2ARAB9APDE4APDE4B | |
| Cadaverine Tartrate SCHEMBL5328277 | 0.93 | MEN1 (0.36) | MEN1KMT2ARAB9APDE4APDE4B | |
| Fumaric Acid SCHEMBL5326133 | 0.93 | MEN1 (0.36) | MEN1KMT2ARAB9APDE4APDE4B | |
| Maleic Acid SCHEMBL5326128 | 0.93 | MEN1 (0.36) | MEN1KMT2ARAB9APDE4APDE4B | |
| Phosphoric Acid SCHEMBL5329669 | 0.92 | MEN1 (0.38) | MEN1KMT2ARAB9APDE4APDE4B | |
| Succinic Acid SCHEMBL5295485 | 0.91 | MEN1 (0.38) | MEN1KMT2ARAB9APDE4APDE4B | |
| Succinic Acid SCHEMBL5326107 | 0.90 | RAB9A (0.46) | MEN1KMT2ARAB9AALDH1A1HTR1A | |
| Succinic Acid SCHEMBL5327837 | 0.88 | HTR1A (0.43) | HTR1AHTR7DRD2HTR2A | |
| Succinic Acid SCHEMBL5327295 | 0.88 | HTR1A (0.38) | MEN1KMT2APDE4DRBP4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007010504-A2 | ACID ADDITION SALTS OF ISOINDOLES ACTING AS ADRENERGIC RECEPTOR ANTAGONISTS | RANBAXY LABORATORIES LIMITED (IN) | 2007-01-25 | — | — | WO | disclosed |