SCHEMBL5330909

SCHEMBL5330909

CSc1ccc2c(c1)c(SC(C)N(C)C)c(C)n2S(=O)(=O)c1ccc(F)cc1

nearest known ligand 0.52

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 12/20 0.52
PTGDR2 Q9Y5Y4 6/20 0.43
PTGDR Q13258 3/20 0.38
LMNA P02545 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5325197 0.92 HTR6 (0.52) HTR6PTGDR2LMNA
SCHEMBL5407866 0.91 PTGDR2 (0.52) HTR6PTGDR2PTGDRLMNA
SCHEMBL5331426 0.90 HTR6 (0.43) HTR6PTGDR2PTGDR
SCHEMBL5420513 0.88 PTGDR2 (0.44) HTR6PTGDR2PTGDRLMNA
SCHEMBL5328962 0.86 PTGDR2 (0.53) HTR6PTGDR2PTGDRLMNA
SCHEMBL5328556 0.85 HTR6 (0.50) HTR6PTGDR2PTGDRLMNA
SCHEMBL5332685 0.85 HTR6 (0.51) HTR6PTGDR2PTGDR
SCHEMBL5331261 0.85 PTGDR2 (0.42) HTR6PTGDR2PTGDRLMNA
SCHEMBL5331491 0.84 HTR6 (0.52) HTR6PTGDR2PTGDRLMNA
SCHEMBL5329965 0.84 PTGDR2 (0.54) HTR6PTGDR2PTGDRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007020653-A1 THIOETHER DERIVATIVES AS FUNCTIONAL 5-HT6 LIGANDS SUVEN LIFE SCIENCES LIMITED (IN) 2007-02-22 WO claimed