SCHEMBL533092

SCHEMBL533092

O=S(=O)(Cl)c1ccc(F)c(F)c1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.40
LMNA P02545 2/20 0.40
TRPV4 Q9HBA0 4/20 0.38
CES2 O00748 1/20 0.38
CES1 P23141 1/20 0.38
PKM P14618 2/20 0.36
KMT2A Q03164 3/20 0.35
MEN1 O00255 2/20 0.35
ALDH1A1 P00352 5/20 0.34
KDM4E B2RXH2 1/20 0.34
GRM4 Q14833 1/20 0.33
TDP1 Q9NUW8 1/20 0.32
MAPT P10636 1/20 0.32
CCR2 P41597 1/20 0.32
POLB P06746 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
DPP4 P27487 1/20 0.31
DPP7 Q9UHL4 1/20 0.31
AKR1C3 P42330 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29668868 1.00 HSD17B10 (0.40) HSD17B10LMNATRPV4CES2CES1
SCHEMBL22034304 0.82 TRPV4 (0.40) HSD17B10LMNATRPV4CES2CES1
SCHEMBL15465525 0.82 TRPV4 (0.40) HSD17B10TRPV4ALDH1A1TDP1CCR2
SCHEMBL4206943 0.80 TRPV4 (0.35) TRPV4
SCHEMBL30681724 0.80 TRPV4 (0.39) HSD17B10LMNATRPV4CES2CES1
SCHEMBL4134828 0.80 TRPV4 (0.39) HSD17B10LMNATRPV4CCR2
SCHEMBL27138022 0.80 TRPV4 (0.39) HSD17B10LMNATRPV4CES2CES1
SCHEMBL29203696 0.80 LMNA (0.42) HSD17B10LMNACES2CES1PKM
SCHEMBL1350979 0.79 LMNA (0.39) HSD17B10LMNACES2CES1PKM
SCHEMBL29543283 0.79 PTGES2 (0.46) HSD17B10TRPV4CES2CES1PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104678028-A Pretreatment and detection method for biogen amine neurotransmitter and detection kit INST PHARM & TOXICOLOGY AMMS 2015-06-03 CN claimed
WO-2025096637-A1 SUBSTITUTED ARYL SULFONAMIDES FOR USE AS SODIUM CHANNEL INHIBITORS XENON PHARMACEUTICALS INC. (CA) 2025-05-08 WO disclosed
US-20250115687-A1 PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, AND CATALYST FOR POLYMERIZAING OLEFINS FORMOSA PLASTICS CORP USA (US) 2025-04-10 US disclosed
WO-2025075722-A1 PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, AND CATALYST FOR POLYMERIZAING OLEFINS FORMOSA PLASTICS CORPORATION, U.S.A. (US) 2025-04-10 WO disclosed
US-20240337928-A1 ORGANIC SALT, PHOTORESIST COMPOSITION INCLUDING THE SAME AND METHOD OF FORMING PATTERN BY USING THE PHOTORESIST PATTERN SAMSUNG ELECTRONICS CO., LTD. (KR) 2024-10-10 US disclosed
CN-118344270-A Fluorine-containing diphenyl sulfone acaricide and preparation method thereof 柳州市惠农化工有限公司 2024-07-16 CN disclosed
CN-118344270-A Fluorine-containing diphenyl sulfone acaricide and preparation method thereof 柳州市惠农化工有限公司 2024-07-16 CN disclosed
CN-112262142-B Benzenesulfonamide compounds and their use as therapeutic agents 泽农医药公司 2023-11-14 CN disclosed
EP-3551626-B1 BENZENESULFONAMIDE COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS XENON PHARMACEUTICALS INC (CA) 2023-10-25 EP disclosed
CN-116355044-A Amide compound, preparation method and application thereof 中国科学院上海药物研究所 2023-06-30 CN disclosed
WO-2000041505-A2 ANTHRANILIC ACID DERIVATIVES WARNER-LAMBERT COMPANY (US) 2000-07-20 WO disclosed
EP-1005453-A1 SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS TULARIK, INC. (US) 2000-06-07 EP disclosed
WO-2000025768-A1 OXADIAZOLE, THIADIAZOLE AND TRIAZOLE DERIVATIVES AND COMBINATORIAL LIBRARIES THEREOF TREGA BIOSCIENCES, INC. (US) 2000-05-11 WO disclosed
US-5936000-A 2-aminoindans as selective dopamine D3 ligands PHARMACIA & UPJOHN COMPANY (US) 1999-08-10 US disclosed
WO-1999031092-A1 BENZAMINE DERIVATIVES MERCK PATENT GMBH (DE) 1999-06-24 WO disclosed
WO-1999010320-A1 SUBSTITUTED BENZENE COMPOUNDS AS ANTIPROLIFERATIVE AND CHOLESTEROL LOWERING AGENTS TULARIK INC. (US) 1999-03-04 WO disclosed
US-5739336-A SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS SYNTEX (U.S.A.) INC. (US) 1998-04-14 US disclosed
EP-0807101-A1 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS PHARMACIA & UPJOHN COMPANY (US) 1997-11-19 EP disclosed
WO-1997000872-A1 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 1997-01-09 WO disclosed
WO-1996023760-A1 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS PHARMACIA & UPJOHN COMPANY (US) 1996-08-08 WO disclosed