SCHEMBL5331238

SCHEMBL5331238

c1ccc2cncc-2cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.63
CYP2A6 P11509 4/20 0.61
ALDH1A1 P00352 3/20 0.61
CYP3A4 P08684 2/20 0.61
CYP1A2 P05177 1/20 0.61
NOTUM Q6P988 1/20 0.53
RAB9A P51151 3/20 0.47
NPC1 O15118 2/20 0.47
MAPK1 P28482 1/20 0.47
IDO1 P14902 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
NFKB1 P19838 1/20 0.46
NFKB2 Q00653 1/20 0.46
RELA Q04206 1/20 0.46
MKNK1 Q9BUB5 2/20 0.45
MKNK2 Q9HBH9 2/20 0.45
CYP19A1 P11511 2/20 0.44
CYP17A1 P05093 1/20 0.44
CYP11B1 P15538 1/20 0.44
CYP11B2 P19099 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21692173 0.84 ATM (0.62) ATMCYP2A6ALDH1A1CYP3A4CYP1A2
SCHEMBL722248 0.84 ATM (0.62) ATMCYP2A6ALDH1A1CYP3A4CYP1A2
SCHEMBL16405704 0.82 CYP2A6 (0.83) ATMCYP2A6ALDH1A1CYP3A4CYP1A2
SCHEMBL29500136 0.82 CYP2A6 (0.83) ATMCYP2A6ALDH1A1CYP3A4CYP1A2
SCHEMBL141605 0.82 CYP2A6 (0.83) ATMCYP2A6ALDH1A1CYP3A4CYP1A2
Biphenyl SCHEMBL28338714 0.82 CYP2A6 (0.83) ATMCYP2A6ALDH1A1CYP3A4CYP1A2
Benzene SCHEMBL27934930 0.80 CYP2A6 (0.94) CYP2A6ALDH1A1CYP3A4CYP1A2SMN1; SMN2
SCHEMBL31124557 0.80 CYP2A6 (0.79) ATMCYP2A6ALDH1A1CYP3A4CYP1A2
SCHEMBL12076750 0.80 MKNK1 (0.57) ATMALDH1A1NOTUMMKNK1MKNK2
SCHEMBL32679826 0.80 CYP2A6 (0.79) ATMCYP2A6ALDH1A1CYP3A4CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007139499-A1 COMPOUNDS FOR USE AS A MEDICAMENT APREA AB (SE) 2007-12-06 WO disclosed
US-5602167-A 4-arylcyclohepta[c] pyrrole analgesics ORTHO PHARMACEUTICAL CORPORATION (US) 1997-02-11 US disclosed
WO-1996036604-A1 4-ARYLCYCLOHEPTA[c]PYRROLE ANALGESICS ORTHO PHARMACEUTICAL CORPORATION (US) 1996-11-21 WO disclosed
US-5523412-A AN UNSUBSTITUTED OR N-ALKYL- OR CYCLOALKYL-SUBSTITUTED PERHYDROCYCLOHEPTA(C)PYRROL-4-ONE ORTHO PHARMACEUTICAL CORPORATION (US) 1996-06-04 US disclosed