Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | USP2 | O75604 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5330405 | 0.88 | ALDH1A1 (0.83) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7977105 | 0.85 | ALDH1A1 (0.69) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL7977108 | 0.85 | ALDH1A1 (0.69) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL11983369 | 0.85 | ALDH1A1 (0.69) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL562989 | 0.82 | ALDH1A1 (1.00) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL4564362 | 0.81 | HPGD (0.68) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL13130280 | 0.81 | TSHR (0.58) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL15504863 | 0.79 | RAB9A (0.70) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 | |
| SCHEMBL5717662 | 0.78 | TSHR (1.00) | ALDH1A1TSHRNPC1RAB9AHDAC1 | |
| SCHEMBL14833395 | 0.78 | CYP1A2 (0.68) | ALDH1A1TSHRCYP1A2CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007015744-A1 | DISUBSTITUTED THIENYL COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2007-02-08 | — | — | WO | disclosed |