Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | YAP1 | P46937 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.50 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12652625 | 0.88 | YAP1 (0.60) | YAP1KDM4EPKMP2RX7MAPT | |
| SCHEMBL3008274 | 0.88 | YAP1 (0.60) | YAP1KDM4EPKMP2RX7MAPT | |
| SCHEMBL3008280 | 0.88 | YAP1 (0.60) | YAP1KDM4EPKMP2RX7MAPT | |
| SCHEMBL5569616 | 0.88 | YAP1 (0.55) | SYKYAP1KDM4EPKMGPR119 | |
| SCHEMBL2999886 | 0.87 | YAP1 (0.62) | YAP1KDM4EPKMP2RX7MAPT | |
| SCHEMBL8147986 | 0.87 | YAP1 (0.62) | YAP1KDM4EPKMP2RX7MAPT | |
| SCHEMBL2999882 | 0.87 | YAP1 (0.62) | YAP1KDM4EPKMP2RX7MAPT | |
| SCHEMBL25245210 | 0.85 | GPR119 (0.59) | SYKYAP1GPR119STSL3MBTL1 | |
| SCHEMBL17591749 | 0.85 | GPR119 (0.59) | SYKYAP1GPR119STSL3MBTL1 | |
| SCHEMBL3661565 | 0.83 | GPR119 (0.57) | SYKYAP1KDM4EPKMGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1804796-A2 | AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES | H.Lundbeck A/S (DK) | 2007-07-11 | — | — | EP | disclosed |
| WO-2006041636-A2 | AMINO SUBSTITUTED ARYLOXYBENZYLPIPERIDINE DERIVATIVES | H.LUNDBECK A/S (DK) | 2006-04-20 | — | — | WO | disclosed |