Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 5/20 | 0.52 |
| ▸ | CA2 | P00918 | 5/20 | 0.52 |
| ▸ | CA9 | Q16790 | 5/20 | 0.52 |
| ▸ | CA12 | O43570 | 4/20 | 0.52 |
| ▸ | CA7 | P43166 | 4/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.52 |
| ▸ | PNLIP | P16233 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CFTR | P13569 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2662773 | 0.84 | LMNA (0.51) | TSHRLMNACA1CA2CA9 | |
| SCHEMBL12313575 | 0.83 | CXCR5 (0.52) | TSHRLMNAALDH1A1CFTRHSD17B10 | |
| SCHEMBL7795902 | 0.83 | IRAK4 (0.51) | TSHRLMNAALDH1A1CFTRHSD17B10 | |
| SCHEMBL31311107 | 0.83 | ALDH1A1 (0.48) | LMNACA1CA2CA9CA12 | |
| Methyl 3-Hydroxy-2-Methoxybenzoate SCHEMBL1050662 | 0.82 | LMNA (0.66) | TSHRLMNACA1CA2CA9 | |
| SCHEMBL7838547 | 0.82 | TSHR (0.43) | TSHRLMNACA1CA2CA9 | |
| SCHEMBL4385204 | 0.81 | LMNA (0.59) | TSHRLMNACA1CA2CA9 | |
| SCHEMBL7842794 | 0.81 | IRAK4 (0.45) | TSHRLMNAALDH1A1CFTRHSD17B10 | |
| SCHEMBL11299803 | 0.77 | IRAK4 (0.49) | TSHRLMNACA1CA2CA9 | |
| SCHEMBL15814877 | 0.77 | IRAK4 (0.51) | TSHRLMNACA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007140317-A2 | USE OF INHIBITORS OF CYTOSOLIC PH0SPH0LIPASE A2 IN THE TREATMENT OF THROMBOSIS | WYETH (US) | 2007-12-06 | — | — | WO | disclosed |
| EP-1451154-A2 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | Wyeth (US) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003048122-A2 | INHIBITORS OF CYTOSOLIC PHOSPHOLIPASE A2 | WYETH (US) | 2003-06-12 | — | — | WO | disclosed |